Mount Sinai has been the site of critically important contributions to the understanding and treatment of cancers. "Now we are developing more targeted, effective treatments and, ultimately, prevention strategies," says Steven J. Burakoff, MD, Director of the Cancer Institute and Professor of Medicine and Oncological Sciences. "This requires the thinking of investigators from many different and sometimes unexpected disciplines." With over 40 percent of the new Center for Science and Medicine devoted to cancer – including two floors of dedicated cancer laboratory research space as well as two floors of dedicated clinical space – investigators work to integrate Mount Sinai's expanding research capacity with its current clinical programs. The Tisch Cancer Institute's outpatient facility, the Ruttenberg Treatment Center, has expanded into a space that is more than double the size of its previous location. "I believe in a large matrix organization that reaches out to all the best minds and ideas," says Dr. Burakoff. "The infrastructure and architecture of the new Cancer Institute brings together the best in cancer care and research, greatly increasing the potential for major discoveries."
Hess Center for Science and Medicine Departments and Institutes
The Mount Sinai Medical Center's Leon and Norma Hess Center for Science and Medicine houses both clinical services and research facilities for some of Mount Sinai Medical Center's most renowned institutes. This spacious, state-of-the-art Center brings physicians, investigators, and specialists from a spectrum of disciplines together in the tireless pursuit of cutting-edge science and innovative medicine.
The Tisch Cancer Institute
The Friedman Brain Institute
Mount Sinai has been recognized as a leader in brain and spinal cord research and treatment for over a century—and that long-standing reputation for excellence will take another leap forward when the Friedman Brain Institute gains two new floors of fully-equipped lab space in the Center for Science and Medicine. "What we're building here is no less than the best neuroscience research institute in the world," says Eric J. Nestler, MD, PhD, director of the Brain Institute and Nash family professor of neuroscience. Designed to facilitate breakthrough research, the new space will support investigators pursuing their best and biggest ideas. Scientists from different disciplines will have the resources they need to explore revolutionary advances, giving patients with nervous system disorders hope for a better life. "Soon—I have no doubt—we will develop tests that will allow us to distinguish between many diseases and their subtypes and to build on those discoveries with the development of new treatments," says Dr. Nestler. "That's when the era of truly personalized medicine will begin for neuroscience, and the Brain Institute is uniquely equipped to get us there."
Cardiovascular Research Institute
Dedicated to eradicating the spread of cardiovascular disease, Mount Sinai's Cardiovascular Research Institute embodies the continuation of a century-old commitment to excellence in patient care, education and medical science. "The Cardiovascular Research Institute has served as a destination for an extraordinary group of world-renowned scientists and clinicians who are fundamentally changing how we think about heart disease," says Roger J. Hajjar, M.D., Director of the Institute. "Our new research and clinical paradigms are laying the foundation for novel therapies based on basic science applied to patients to combat cardiovascular diseases" says Valentin Fuster, MD, PhD, Director of Mount Sinai Heart Center. The Institute's new customized research space in the Center for Science and Medicine was designed to support this new paradigm, advancing the work of investigators striving to expand human knowledge of cardiovascular pathology. The rapid translation of innovative research concepts into prevention, diagnosis and therapy will mean that patients of all ages struggling with cardiovascular diseases can look forward to multidisciplinary treatments of unprecedented quality.
Genomics and Multiscale Biology
As the hub of genomics research at the Icahn School of Medicine at Mount Sinai, the Institute for Genomics and Multiscale Biology promises to be at the forefront of the revolution in genetics and genomic sciences, which will fundamentally change the practice of medicine. "You can imagine back in the day of Louis Pasteur, when the microscope came to be, it opened up a whole new world of investigation and exploration for understanding living systems," says Eric Schadt, PhD, Director of the Institute for Genomics and Multiscale Biology, Chair of the Department of Genetics and Genomic Sciences, and Jean C. and James W. Crystal Professor of Genomics. "That's sort of what we have in these new technologies." Multiscale biology is a departure from the prevailing model for exploring the human system, and Dr. Schadt's new, global perspective on understanding biology is nothing short of a paradigm shift in the scientific world. When the Institute takes up residence in the Center for Science and Medicine, the large-scale generation and integration of multiple sources of biological data combined with clinical information will expand Mount Sinai's ability to characterize disease, and ultimately help improve the diagnosis and treatment of patients.
Child Health and Development Institute
Dedicated to improving the lives of infants, children, and adolescents, the Child Health and Development Institute (CHDI) will dramatically enhance its research capacity when it expands into the new Center for Science and Medicine. "Children have unique vulnerabilities with no counterpart in adult life, and their biology and vulnerability to illness evolve as they mature from infancy to adolescence," says Bruce D. Gelb, MD, Gogel Family Chair and Director of the Child Health and Development Institute." The CHDI will explore that unique biology by fostering an intellectually rich and supportive environment for collaborative scientific investigation. Integrating the latest technologies with a modern research layout, the new space is designed to advance the development of innovative paradigms for understanding the effects of genetics and environment on child health, as well as personalizing pediatric medicine. Mount Sinai's vast resources will position the Child Health and Development Institute to become one of the world's leading centers of children's health research.
Learn more about the Child Health and Development Institute
Translational and Molecular Imaging
Biomedical imaging in the twenty-first century offers unparalleled opportunities to transform clinical medicine, and the Translational and Molecular Imaging Institute will advance that transformation by serving as a research catalyst for a new generation of imaging methodologies. "We will be among the first in the world to combine an MRI and PET in a single machine…which will lead to earlier detection of disease and also more targeted treatments," says Zahi A. Fayad, PhD, Director of the Translational and Molecular Imaging Institute. With its expansion to a state-of-the-art space in the Center for Science and Medicine, the Institute will be positioned to take visualization technology to new levels, inventing and applying methodologies that will enable breakthroughs across Mount Sinai's other disciplines. The Institute will support collaborative opportunities by providing researchers and clinicians from our various institutes with greater and more comprehensive access to complex imaging equipment—including emerging modalities like bioluminescent and fluorescent imaging—dramatically increasing the potential for making major discoveries at Mount Sinai.
Learn more about the Translational and Molecular Imaging Institute
Eric J. Nestler, MD, PhD, is Director of the Friedman Brain Institute, the Nash Family Professor and Chair of the Department of Neuroscience, and Professor of Psychiatry and of Pharmacology and Systems Therapeutics. His lab studies the molecular mechanisms of drug addiction and depression. Read More
Valentin Fuster, MD, PhD, is Director of the Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Heart, and the Marie-Josée and Henry R. Kravis Center for Cardiovascular Health. He is the Richard Gorlin, MD/Heart Research Foundation Professor. Read More
Eric E. Schadt, PhD, is the Director of the Institute for Genomics and Multiscale Biology, Chair of the Department of Genetics and Genomics Sciences, and Jean C. and James W. Crystal Professor of Genomics.
Bruce D. Gelb, MD, Gogel Family Chair and Director of The Mindich Child Health and Development Institute, Director of the Center for Molecular Cardiology, and Professor of Pediatrics and Genetics & Genomic Sciences Read More
Zahi A. Fayad, PhD, is Director of the Translational and Molecular Imaging Institute; Professor of Radiology and Medicine (Cardiology); Director and Founder, the Eva and Morris Feld Imaging Science Laboratories; and Director, Cardiovascular Imaging Research. Read More
Steven J. Burakoff, MD, is Director,
The Tisch Cancer Institute; Professor of Medicine, Hematology, and Medical Oncology; and Professor of Oncological Sciences; and Lillian and Henry M. Stratton Professor of Cancer Medicine. In 2009 he received the Lifetime Achievement Award from the American Association of Immunologists. Read More