Mount Sinai Researchers Establish Link between Amyotrophic Lateral Sclerosis and the Body's Response to Viral Infection

 – April 6, 2015  –– 

In a recent study published in the journal Nature Immunology, researchers at the Icahn School of Medicine at Mount Sinai found that a human protein called senataxin (SETX), which has been found to be associated with neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), plays an important role in the response to viral infection. "We knew this protein was important, but its precise activity and role in the antiviral response had never been demonstrated before," said Harm van Bakel, PhD, co-author of the paper. "This is a protein implicated in neurodegenerative disease that has now been linked to our innate antiviral mechanism, and it offers an intriguing clue to a relation between the inflammatory response and these diseases," said Ivan Marazzi, PhD, co-author of the paper in the news release.

-Honoratus Van Bakel, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
-Ivan Marazzi, PhD, Assistant Professor, Microbiology, Icahn School of Medicine at Mount Sinai

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