Researchers Explore Drug Combinations that Reduce Adverse Effects
Researchers using data from the FDA’s Adverse Event Reporting System (FAERS) have hypothesized that certain drug combinations can be used to mitigate serious adverse events. They have tested their hypothesis with an animal model to determine the mechanisms of action by which these drugs interact. According to a study <http://stm.sciencemag.org/content/5/206/206ra140> published in the journal Science Translational Medicine, this could be the starting point for the development of clinical trials. Lead author Ravi Iyengar, PhD, Professor of Pharmacology and Systems Therapeutics, and Director of the Systems Biology Center at the Icahn School of Medicine at Mount Sinai, said that after studying different drug combinations in FAERS, the researchers noticed that the first drug had different levels of adversity when combined with different second drugs.
–Dr. Ravi Iyengar, Dorothy H. and Lewis Rosenstiel Professor, Pharmacology and Systems Therapeutics, Director, Systems Biology Center, Icahn School of Medicine at Mount Sinai