Wise Buy? Drugs for Alzheimer's Dementia

 – February 24, 2015  –– 

On Sunday night when Julianne Moore collected an Oscar for her performance in the movie "Still Alice" when she portrayed a woman dealing with early-onset Alzheimer's disease, she noted that Alzheimer's is not only an incurable condition, but also "an incredibly isolating one." Four drugs are commonly prescribed for Alzheimer's dementia. Three of them are cholinesterase inhibitors, which "inhibit the enzyme that breaks down acetylcholine in the synapse," said Howard Fillit, MD, clinical professor of geriatrics and neuroscience at The Mount Sinai Hospital in New York City and chief science officer of the Alzheimer's Drug Discovery Foundation. "The benefits of cholinesterase inhibitors and Namenda are way overblown," said Samuel Gandy, MD, a neurologist who is also at The Mount Sinai Hospital in New York.

- Dr. Samuel Gandy, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai
- Dr. Howard Fillit, Clinical Professor, Geriatrics and Palliative Medicine, Neuroscience, Medicine, Icahn School of Medicine at Mount Sinai

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