Study: Immune Cells outside the Brain may Regulate Propensity to Develop Depression

 – December 13, 2013  –– 

A new study shows that immune cells outside the brain may regulate propensity to develop depression. The data were presented today at the American College of Neuropsychopharmacology (ACNP) Annual Meeting. In a study, led by Georgia Hodes, MD, Postdoctoral Fellow of Neuroscience at the Icahn School of Medicine at Mount Sinai, the effects of the circulating pro-inflammatory immune chemical called interleukin-6 on depression-like behaviors was investigated in rodents. The investigators found that rodents with increased propensity to show depression-like behaviors had elevated levels of circulating interleukin-6, suggesting that individual differences in the peripheral immune system contributes to vulnerability to developing depression.

-Dr. Georgia Hodes, Postdoctoral Fellow, Neuroscience, Icahn School of Medicine at Mount Sinai

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