Cocaine Users Have a Hard Time Predicting Loss

 – February 9, 2015  –– 

In people with a cocaine addiction, brain circuits responsible for predicting emotional loss become impaired, according to new research conducted at the Icahn School of Medicine at Mount Sinai in New York. That is one reason why many continue to use the drug even after facing devastating consequences such as imprisonment or the loss of a relationship. “We found that people who were addicted to cocaine have impaired loss prediction signaling in the brain,” said Muhammad Parvaz, PhD, lead author of the study. “This is the first time a study has targeted the prediction of both gains and losses in drug addiction, showing that deficits in prediction error signaling in cocaine addicted individuals are modulated by recent cocaine use,” said principal investigator Rita Goldstein, PhD, professor of psychiatry and neuroscience.

- Muhammad Parvaz, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai
-Rita Goldstein, PhD, Professor, Psychiatry, Neuroscience, Icahn School of Medicine at Mount Sinai

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