The Scientist -Autophagy's Role in Alzheimer's - Abby Olena
Pathological hallmarks of Alzheimer's disease (AD) include the aggregation of amyloid beta (Aβ) peptides inside neurons and the accumulation of extracellular Aβ plaques. A paper published in Cell Reports shows that Aβ leaves neurons in an autophagy-dependent manner, and suggests that aggregation of intracellular Aβ contributes to AD pathology. "It looks like autophagy plays a big role here. They did a great initial observation to really set a tone that we have to pay attention to another important part of autophagy," said Zhenyu Yue, MD, a Professor of Neurology and Neuroscience at the Icahn School of Medicine at Mount Sinai.
-Dr. Zhenyu Yue, Professor, Neurology, Neuroscience, Icahn School of Medicine at Mount Sinai