Mount Sinai Researchers Present Findings on Imaging and Sex-Based Differences at the Society for Cardiovascular Angiography and Interventions (SCAI) 2016 Scientific Sessions

New York, NY
 – May 6, 2016 /Press Release/  –– 

Researchers from the Icahn School of Medicine at Mount Sinai presented their late-breaking clinical trial findings and other important research results advancing the field of interventional cardiovascular medicine at the Society for Cardiovascular Angiography and Interventions (SCAI) 2016 Scientific Sessions in Orlando, Fla., from May 4 to 7.

Late-breaking clinical trial presentations included:

Effect of the AVERT™ Contrast Modulation System on Contrast Dose Reduction and Acute Kidney Injury after Coronary Angiography and PCI

In the largest study of its kind, a new device has been found to significantly reduce the volume of radiographic dye without decreasing image quality in patients who are at risk of developing acute kidney injury (AKI) after undergoing a coronary angiography or percutaneous coronary intervention (PCI). The device — known as AVERT™ — did not, however, reduce contrast-induced AKI (CI-AKI). With AVERT, the operator can control the volume of dye used during an interventional procedure.  Once the appropriate amount of dye has been injected into the coronary, the remaining dye goes into a reservoir, rather than into the aorta.

The AVERT results were presented at SCAI on Wednesday, May 4, 2016 at 1:15 pm ET as a late-breaking clinical trial by lead study author Roxana Mehran, MD, FSCAI, Director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai. Dr. Mehran reported a research grant from Osprey Medical for this study.

Plaque Morphology Predictors of Side Branch Occlusion after Provisional Stenting in Coronary Bifurcation Lesion: Results of Optical Coherence Tomography Bifurcation Study (ORBID)

In a new study using optical coherence tomography (OCT), an invasive laser imaging technique that provides high-resolution images, researchers found that maximum lipid arc and the presence of lipid plaque contralateral to the side branch (SB) ostium before stenting may contribute to significant side branch ostium stenosis (SBOS) after stenting.

The results of the ORBID study were presented at SCAI on Thursday, May 5, 2016 at 10:30 am ET as a late-breaking clinical trial by study investigator Samin Sharma, MD, FSCAI, Director of Clinical Cardiology and Intervention, Dean of International Clinical Affiliations, and President of the Mount Sinai Heart Network at The Mount Sinai Hospital.

This paper was published online in Catheterization and Cardiovascular Interventions, the official publication of SCAI. The study was sponsored by Boston Scientific Corporation.

Sex Based Differences in Outcomes with Transcatheter Aortic Valve Therapy: From STS/ACC TVT Registry

Data from one of the largest national registries of transcatheter aortic valve replacement (TAVR) patients shows that although women are more likely to experience vascular complications in the hospital, their one-year survival rate is more favorable than men. The study demonstrated that women were treated more often using non-transfemoral access (45 percent vs. 34 percent) with smaller sheath and device sizes but had a higher valve cover index than men. Post-procedure, women experienced more in-hospital vascular complications than men (8.27 percent vs. 4.39 percent, adj HR 1.70, 95 percent CI 1.34 – 2.14, p < 0.001) along with a trend for more bleeding (8.0 percent vs. 5.96 percent, adj HR 1.19, 95 percent CI 0.98 – 1.44, p = 0.08).

This STS/ACC TVT Registry™ analysis was presented at SCAI on Friday, May 6, 2016 at 9:00 am ET as a late-breaking clinical trial by primary author Jaya Chandrasekhar, MBBS, MRCP, FRACP, a post-doctoral research fellow with Roxana Mehran, MD, FACC, FAHA, FSCAI, at the Icahn School of Medicine at Mount Sinai.
Sex-based Differences in Patients &IE 55 Years of Age Undergoing PCI for Acute Coronary Symptoms

Women younger than 55 years of age who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) are more likely to experience one-year adverse cardiovascular events due to risk factors such as diabetes and chronic kidney disease, yet they are less likely to receive potent antiplatelet therapy than men. The PROMETHEUS study found that outcomes for both men and women post-PCI are dependent on their baseline risk factors, not their sex.

The results were presented at SCAI on Friday, May 6, 2016 at 9:15 am ET as a late-breaking clinical trial by study co-principal investigator Usman Baber, MD MS, Assistant Professor of Medicine at the Icahn School of Medicine at Mount Sinai.

About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,100 primary and specialty care physicians; 12 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. Physicians are affiliated with the renowned Icahn School of Medicine at Mount Sinai, which is ranked among the highest in the nation in National Institutes of Health funding per investigator. The Mount Sinai Hospital is ranked as one of the nation’s top 10 hospitals in Geriatrics, Cardiology/Heart Surgery, and Gastroenterology, and is in the top 25 in five other specialties in the 2015-2016 “Best Hospitals” issue of U.S. News & World Report. Mount Sinai’s Kravis Children’s Hospital also is ranked in seven out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology, while Mount Sinai Beth Israel is ranked regionally.

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