4D Technology Development Program Award
The 4D Technology Development Program is focused on supporting faculty and post-doc technology development at the Icahn School of Medicine at Mount Sinai to effectively and efficiently move new technologies through a process of discovery, design, development, and delivery.
Winners: Sander Houten, PhD; Sarah J. Miller, PsyD; Christopher Strother, MD; and Douglas B. Unis, MD
Description: In this project, Dr. Houten and co-workers are trying to identify a small molecule enzyme inhibitor for substrate reduction therapy of an inborn error of metabolism. The investigators characterized the target enzyme and built a comparative molecular model of the protein structure. Through computational screening they identified 3 inhibitor candidates that are currently under further investigation.
Dr. Miller is developing an app to improve African Americans’ screening colonoscopy uptake. She created a prototype of the app and obtained collaborative feedback from key stakeholders including community members, healthcare providers and research experts. The programmed app is currently undergoing beta testing. Preliminary results have been disseminated to national and international audiences.
The aim of Dr. Strother's project is to study the effects of various lighting spectrum, using a novel lighting system, on the performance of emergency physicians doing simulated clinical procedures. Clinical performance, such as the number and severity of errors and the time it takes to complete the procedure, will be assessed in a simulated clinical environment at the Mount Sinai Hospital Emergency Department Simulation, Teaching, and Research Center (ED-STAR Center) in New York City. This will provide a framework and baseline data to test other lighting conditions to improve patient safety and health care quality.
Emerging technologies of surgical robotics, 3D mapping and modeling of anatomic images, and 3D printing of titanium implants using electron beam melting are ushering in a new era in orthopaedic implant design, manufacture and implantation. Convergence of these technologies allow Dr. Unis' group to create miniaturized custom hip replacement implants that spare bone while at the same time achieve unprecedented cortical bone contact and thus stability.