Mount Sinai Innovation Awards

On Monday, October 24, 2016, the Icahn School of Medicine at Mount Sinai hosted the 2nd annual Mount Sinai Innovation Awards, celebrating six honors that recognize significant contributions in biomedical education and industry.

Through the dedication of presenters, participants, attendees, and our generous sponsors, SINAInnovations and the Innovation Awards continue to showcase and inspire incredible ingenuity and advances in research, technology, medicine, and health care.

Inventor of the Year

The Mount Sinai Inventor of the Year Award has been created to recognize individual or collaborative investigators in the Mount Sinai Health System whose research is making, or has the potential to make, significant positive and product-driven impacts on health.

Winner: Dennis S. Charney, MD

Description: Dennis S. Charney, MD’s work in depression has led to new hypotheses regarding the mechanisms of antidepressant drugs and discovery of new and novel therapies for treatment resistant depression including Lithium and Ketamine. The work demonstrating that Ketamine is a rapidly acting antidepressant has been hailed as one of the most exciting developments in antidepressant therapy in more than half a century.

Faculty Idea Prize 

The Faculty Idea Prize is designed to highlight a collaborative, innovative, research idea by young investigators that can potentially be translated into a marketable product. The results of the collaborative project idea should go beyond what is possible through individual PI-driven research, and should enable launching of a multidisciplinary project that can create value through the development of therapeutics, devices, diagnostics, or digital health applications.

Winners: Roland H. Friedel, PhD & Nadejda M. Tsankova, MD, PhD

Description: Glioblastoma remains a rapidly fatal brain tumor. Zika virus has natural predilection for fetal neural stem cells, which bear striking similarities to glioblastoma cells. Nadejda M. Tsankova, MD PhD and Roland H. Friedel, MD will thus investigate the potential of Zika to specifically infect glioblastoma cells and trigger their cell death, uncovering novel therapeutic strategies for this deadly disease.

Dean's Healthcare System Team Science Award

The Annual Dean’s Healthcare System Award, sponsored by Conduits, the Institute for Translational Sciences, has been established to acknowledge and underscore the emerging importance of interdisciplinary teams to the translation of research discoveries into clinical applications.

Winner: MECONIUM Study Team - Inga Peter, PhD; Jose Clemente, PhD; Jean-Frederick Colombel, MD; Jeremiah Faith, PhD; Jianzhong Hu, PhD; Joanne Stone, MD; and Joana Torres, MD

Description: The MECONIUM Study aims to compare the bacterial profiles of pregnant women with and without Inflammatory Bowel Disease (IBD) and their newborn babies. The goal is to explore the role of genetic make-up, disease activity throughout pregnancy, medications and clinical features on the bacterial composition of the baby. In addition, we will assess if feeding behavior (breastfeeding versus formula) and/or antibiotic use early in life help modify the microbiome. 

4D Technology Development Program Award

The 4D Technology Development Program is focused on supporting faculty and post-doc technology development at the Icahn School of Medicine at Mount Sinai to effectively and efficiently move new technologies through a process of discovery, design, development, and delivery.

Winners: Sander Houten, PhD; Sarah J. Miller, PsyD; Christopher Strother, MD; and Douglas B. Unis, MD

Description: In this project, Dr. Houten and co-workers are trying to identify a small molecule enzyme inhibitor for substrate reduction therapy of an inborn error of metabolism. The investigators characterized the target enzyme and built a comparative molecular model of the protein structure. Through computational screening they identified 3 inhibitor candidates that are currently under further investigation.

Dr. Miller is developing an app to improve African Americans’ screening colonoscopy uptake. She created a prototype of the app and obtained collaborative feedback from key stakeholders including community members, healthcare providers and research experts. The programmed app is currently undergoing beta testing. Preliminary results have been disseminated to national and international audiences.

The aim of Dr. Strother's project is to study the effects of various lighting spectrum, using a novel lighting system, on the performance of emergency physicians doing simulated clinical procedures. Clinical performance, such as the number and severity of errors and the time it takes to complete the procedure, will be assessed in a simulated clinical environment at the Mount Sinai Hospital Emergency Department Simulation, Teaching, and Research Center (ED-STAR Center) in New York City. This will provide a framework and baseline data to test other lighting conditions to improve patient safety and health care quality.

Emerging technologies of surgical robotics, 3D mapping and  modeling of anatomic images, and 3D printing of titanium implants using electron beam melting are ushering in a new era in orthopaedic implant design, manufacture and implantation. Convergence of these technologies allow Dr. Unis' group to create miniaturized custom hip replacement implants that spare bone while at the same time achieve unprecedented cortical bone contact and thus stability. 

Quod Erat Demonstrandum (Q.E.D.) Award

The Q.E.D. Project is designed to provide a hands-on, team-based, problem-solving experience for students and trainees. Over the course of an academic year, student-led teams will define a specific problem and build a prototype solution for it. These solutions will be evaluated based on innovation, practicality, ease of use and adoption, economic impact, and commercial potential.

Winner: Multis - Kieran Chacko, Brandon Hogstad, Michela Masi Leone, David Sachs, Olivia Torre

Description: Multis is developing a handheld diagnostic tool designed to reach patients in low-resource areas. Our device leverages innovative biotechnology to rapidly screen for multiple diseases in one low-cost, reliable test. Built for the field, our temperature-resistant technology will be compatible with geotagging software to inform need-driven public health interventions.

SINAIMedMaker Challenge

The SINAIMedMaker Challenge is a healthcare technology competition and a new satellite event of SINAInnovations. Multidisciplinary teams will aim to create novel solutions for the management, monitoring, and treatment of Pain and Fatigue. These problems can be addressed by the following technology solution categories: Assessment & Characterization Frameworks, Tracking & Monitoring Devices/Platforms, Decision-Making Management Apps, and Therapeutic Apps & Devices.

Winners: 1st Place - PT Partner ; 2nd Place - Sickle Me Not ; 3rd Place - bioLumen

Description: Adherence to high quality physical therapy greatly improves functional recovery and reduces chronic pain after knee surgery, such as total knee arthroplasty.  PT Partner created a wearable device that surrounds the knee and ankle joint which can track the patient’s physical therapy course via a phone application, provide real-time feedback to the patient while they complete their therapy, and report important metrics to their care provider such as completion of scheduled exercise, range of motion and daily activity.

SickleMeNot is a multi-platform application for managing and engaging pediatric sickle cell patients.

bioLumen is a noninvasive biofeedback therapy that treats lumbar muscle tension, a component of chronic low back pain. The system analyzes electromyography of the back muscles in relatime to control room lighting color, music, and more in a patient's home environment. Session data can also be uploaded to EMRs for clinical review.


Event Presenters: Ashish Atreja, MD, MPH, Kevin D. Costa, PhD, Lakshmi A. Devi, PhD, Scott L. Friedman, MD, Janice L. Gabrilove, MD, Basil Hanss, PhD, and Erik Lium, PhD

Event Hosts: SINAInnovations, Mount Sinai Innovation Partners (MSIP), CONDUITS - Institutes for Translational Sciences, Office of Academic Development & Enrichment (OADE), and Graduate School of Biomedical Sciences

Premier Sponsor

Jones Day

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