The Mount Sinai Department of Oncological Sciences
The Mount Sinai Department of Oncological Sciences is dedicated to reducing the burden of cancer through research. Our goal is to turn these research advances into improved cancer interventions.
The Department of Oncological Sciences has two divisions, Cancer Biology, and Cancer Prevention and Control.
This research program includes primary and joint investigations aimed at:
- A molecular understanding of the cellular processes and signaling pathways involved in the initiation and progression of human cancers
- Insights into molecular targets for innovative therapeutics
Research themes within the Cancer Biology Program include:
- Receptor and cytoplasmic regulatory pathways, including tyrosine kinase receptors, G proteins, Wnt ligands, cytokines, interleukin, interferon, and TGF beta
- Oncogenes and tumor-suppressor genes with implications for cell cycle regulation, apoptosis, growth arrest, and senescence
- Cell adhesion, including catenins and cadherins, as well as altered signaling in metastasis
- Regulation of protein stability, including studies on the role of bTRCP and its components in the regulation of b-catenin, IkB stability, and Hlf1, and in the regulation and functional significance of protein sumoylation
- Structural and macromolecular interactions in signaling pathways using X-ray crystallography and nuclear magnetic resonance technology
Cancer Prevention and Control
The Department of Oncological Sciences’ research program includes primary and joint faculty engaged in investigations to increase understanding of the role of psychological, social, and biobehavioral factors in the prevention of cancer and in the control of adverse sequelae of cancer and its treatment.
The program's efforts focus on three distinct areas: research, education, and outreach.
Current research includes the investigation of factors affecting:
- Participation in cancer screening and genetic testing
- Lifestyle modification to reduce cancer risk
- Biobehavioral factors in adjusting to cancer and its treatment
- Long-term adjustment of cancer survivors and their families
Educational effort includes two postdoctoral training programs: one directed toward psychosocial issues in breast cancer; the other directed toward issues in cancer prevention and control. Our cancer outreach efforts focus both on increasing cancer knowledge and awareness and on increasing the participation of medically underserved groups in cancer research.
Icahn Medical Institute, Room 15-70
One Gustave L. Levy Place
New York, NY 10029