The Division is actively engaged in basic science research, patient-oriented research, and translational research linking these areas. The research of the Division is internationally recognized and the faculty have been very successful in competing for peer-reviewed extramural support for their work. Ongoing funding is provided by the National Institutes of Health (NIH), the Polycystic Kidney Research Foundation, National Kidney Foundation, Kidney and Urology Foundation of America, and the American Heart Association.
Among the Division's basic research initiatives are studies of how the kidney regulates fluids and electrolyte balance in health and disease (polycystic kidney disease). Methodologies available for investigating these topics are state-of-the-art and include isolated perfused tubules, fluorescent ratio imaging, microcalorimetry, electrophysiology, radioisotope tracer technology, DNA and RNA analysis, southern and northern blotting, polymerase chain reaction techniques, oocyte expression, and yeast two-hybrid techniques. The molecular mechanisms underlying proteinuria (the major feature of nephrotic syndrome) and the genetics of congenital renal disease (vesicoureteral reflux) are also being actively investigated by divisional scientists. The Divisional team works closely with the wider Mount Sinai Renal Medicine research group in the area of polycystic kidney disease and HIV-related kidney disease. Advanced imaging, computational, genetic, and other analytic devices are routine tools for the Division's scientists.
Clinical research faculty of the Division are funded by the NIH to study cardiovascular and lipid-related disease in persons with chronic kidney conditions. In addition, the Division is actively participating in several collaborative studies, including the North American Pediatric Transplant Cooperative Study (NAPRTCS) and the New York/New Jersey Collaborative Studies Group. The Division is a participating site in the NIH-funded multicenter Chronic Kidney Disease in Children (CKiD) study and the Focal Segmental Glomerulosclerosis (FSGS) study. Also, the Division is one of few in the nation to support an NIH protocol to provide kidney transplants to children with HIV infection. The Division welcomes questions about and requests to participate in these studies.