Jaime Silva de Lima, Ph.D.

Dr. Jaime Lima, an expert in toxicology and biochemistry, is an Associate Professor in the University of Rio de Janeiro. He was awarded the Irving J. Selikoff Scholarship in 1996 to support the conduction of an assessment of the health of workers exposed to pesticides. Dr. Lima worked with Steven Markowitz, MD, while at Mount Sinai / Queens Colllege. Additional research interests include toxicology, occupational and environmental health and epidemiology.

Institutional Affiliation

LACAT – Laboratório de Análises Clínicas, Ambientaise Toxicológicas
Instituto Biomédico
Universidade do Rio de Janeiro – UNIRIO

Mailing Address

Universidade do Rio de Janeiro – UNIRIO
Instituto Biomédico
Rua Frei Caneca, 94 – Centro
Rio de Janeiro – RJ
CEP 20211-040

E-mail Address


Irving J. Selikoff Scholarship Project

Occupational Health Assessment of Organophosphorus Pesticides Exposure on Fieldworkers

This project means to determine the relationship between levels of RBC acetylcholinesterase present in a “ghost” membrane fraction, plasma cholinesterase, paraoxonase and exposure to organophosphates in a group of workers from two crop areas located at the State of Rio de Janeiro.

We will also determine biomarker exposure levels, i.e., urinary p-nitrophenol, monomethylphosphate (MMP), dimethyl phosphate (DMP), diethylphosphate (DEP), dimethylthiophosphate (DMTP), diethylthiophosphate (DETP), dimethyldithiophosphate (DMDTP), diethyldithiophosphate (DEDTP) and phenylphosphonic acid. All of these metabolites are the so called alkyl phosphates. We intend to determine the relationship between metabolite levels and degree of organophosphate exposure in order to hone in on the possible correlation between their levels and cholinesterase inhibition.

Partial Bibliography

Jaime S. Lima; Josino C. Moreira; Silvana C. Jacob; Alberto J. Araújo; Mônica O. Soares; Alexandre H. Kubota ; Marcos C. Monassa; Alexandre M. Amaral e Steven Markowitz. 2003. Riscos Coletivos e Impacto do Uso de Agrotóxicos Sobre a Saúde Humana e Ambiental: Um Estudo Piloto de Saúde Ocupacional. Revista Meio Ambiente e Desenvolvimento, Universidade Federal do Paraná. In Press.

Josino C. Moreira1; Silvana C. Jacob1; Jaime S. Lima2; Frederico Peres1; Armando Meyer1; Jefferson J. Oliveira-Silva1,2; Paula N. Sarcinelli1; Darcilio F. Batista1; Mariana Egler1; Mauro V. Castro Faria4 ;Alberto José de Araújo3; Alexandre H. Kubota;1 Monica de O. Soares2; Sergio R. Alves1; Claudia M. Moura4; Rosane Curi1. 2002. Avaliação integrada do impacto do uso de agrotóxicos sobre a saúde humana em uma comunidade agrícola de Nova Friburgo, RJ Ciência e Saúde Coletiva, 7 (2), 299-312.

Published abstract: J.S. Lima; A. Kubota; A. Meyer; J.C. Moreira and S. Markowitz. A New Method to Analyze p-Nitrophenol and p-Nitrocresol in Urine Using HPLC. 1998. The Toxicologist, 42 (1-S), 155.

Koifman,S; Ferraz, I.; Viana, T. S.; Silveira, C.L.P.; Carneiro, M.T.D.; Koifman, R.; Sarcinelli P. N.; Mattos, R.C.O.C.; Lima, J.S.; Silva, J.J.O.; Moreira, J.C.; Ferreira, M. F. A.; Fernandes, C and Bulcão, A.C. 1998. Cancer Cluster among young Indian Adults living near power transmission lines in Bom Jesus do Tocantins, Pará. Public Health, 14 (3), 161-172.

de Lima JS, Bastos Neto Jda D, Bastos VL, da Cunha JC, Moraes FF, Ferreira Mde F, Moreira Jda D, Faria MV. Methyl parathion activation by a partially purified rat brain fraction. Toxicol Lett. 1996 Sep; 87(1):53-60.