Gustavo R Contreras, M.D.

Dr. Contreras, is a Medical Doctor who specializes in respiratory diseases, and occupational medicine. He is currently the technical director of the Technical and Scientific Foundation of one of Chile’s largest health providers, the Asociación Chilena de Seguridad. He is also a professor of Occupational Medicine in the University of Chile’s School of Public Health. Dr. Contreras was awarded the Irving J. Selikoff Schoalrhsip in 1996 and he worked with Jaime Zseinuck, MD on the subject of occupational asthma in Chile. Dr. Contreras’ research interests also include gene factors related to occupational asthma and diseases related to work in high altitudes.

Institutional Affiliation

Asociación Chilena de Seguridad
University of Chile School of Public Health

Mailing Address

Fundación Científica y Tecnológica ACHS
Asociación Chilena de Seguridad
Jofré 039, Departamento 31
Santiago
CHILE

E-mail Address

fctgct@gw.achs.cl

Irving J. Selikoff Scholarship Project

Study of Factors Associated with the Development of Occupational Asthma Induced by Low and High Molecular Weight Agents

Occupational asthma is a frequent disease among workers. Its prevalence and incidence in Chile are unknown. Current knowledge suggests that occupational asthman is mostly an immonological disease with a genetic component. The main objective of this proposal is to study the factors associated witht he development of occupational asthman induced by low and high molecular weight agents in Chile. To accomplish this objective, two cohort studies, three case-control studies and one case-control study nested in a cohort will be conducted.

The incidence and prevalence of diisocyanate and wheat flour asthman will be analyzed from a cohort initiated in 1992 by the respiratory unit of the Department of Occupational Medicine of the Asociación Chilena de Seguridad in Santiago, Chile. The incidence and prevalence will be calculated annually starting in 1997. To analyze the immonological and genetic characteristics of diisocyanate and wheat flour asthma, two concurrent case-control studies will be conducted. Skin prick tests, IgE levels, Lymphocyte Helper subsets (Th1 and Th2) and HLA class II DQ, DR, 11q and 5q genes will be analyzed. A tirad case-control análisis will be developed to compare diisocyanate and wheat flour immonological and genetic characteristics.