A Randomized, Double-Blind, Crossover Trial of Mifepristone in Gulf War Veterans with Chronic Multisymptom Illness

ID Number 3293-07-048

Contact Information

Melissa Rothstein
Tel: 718-584-9000 x6567
E-mail: melissa.rothstein@va.gov

Markay Hopps
Tel: 718-584-9000 x6587
E-mail: markay.hopps@va.gov

If you are a Gulf War veteran and may have chronic multisymptom illness (i.e. Gulf War syndrome), a condition is characterized by multiple symptoms including headache, fatigue, joint and muscle pain, rashes, breathing complaints, gastrointestinal symptoms, depression, and problems with attention or memory, you may be eligible to participate in this treatment study.

The purpose of this study is to determine whether a medication called mifepristone is effective in improving the health and the memory and attention span of Gulf War veterans with chronic multisymptom illness.

Participation in this study will last about 5 to 6 months and will include approximately 11 outpatient visits in the PTSD clinic of the Bronx VA Medical Center. Eligible participants will go through the following steps:

  • A comprehensive medical and psychological evaluation, including self-report questionnaires, a physical examination and medical history, laboratory testing, and a psychiatric interview
  • Two consecutive blood draws and a 24-hour at-home urine collection
  • Two treatment phases which consist of six weeks of treatment on mifepristone (200 mg/day) and six weeks of placebo treatment (i.e., a “sugar pill”), separated by one month
  • A four week follow-up phase following the second treatment phase
  • Collection of blood samples so that we can measure before-treatment and after-treatment levels of biological variables that are affected by the medication
  • 5 sessions of neurocognitive tests involving memory and attention, approximately 1.5 hours long

Read more about this study

You will be compensated for your time and travel up to $550. You will not be charged for any treatments or procedures that are conducted as part of this study. Please call Melissa Rothstein at 718-584-9000 x6567 or Markay Hop at 718-584-9000 x6587 if you are interested in participating or have any questions.