The Departmental Structural Biology and Biophysics Core (SBBC) houses equipment for NMR spectroscopy, X-ray crystallography and molecular biophysics. The NMR facility has two Bruker DRX 600 MHz and DRX 500 MHz spectrometers. Both NMR instruments are configured with four RF channels and triple-axis pulsed-field gradients, and equipped with a 5 mm triple-resonance (1H/13C/15N) PFG probe and a deuterium lock switch for deuterium decoupling experiments essential for structural studies of proteins. In addition, the 500 MHz NMR is equipped with a high-sensitivity cryogenic probe and an automatic sample changer. The X-ray crystallography facility has two Rigaku RU-H3RHB (18 kW) X-ray generators, three RAXIS-IV Imaging plate area detectors, one Huber precession camera, three Oxford Cryostat low-temperature devices, and two confocal mirror systems, and one Yale system. Other major molecular biophysics instruments at the SBBC include a MicroCal Isothermal Titration Calorimetry system, a Beckman XLI Analytical Ultra-Centrifuge, a Dynamic Light Scattering Device, a Jasco (J-810) Circular Dichroism Spectrometer, a Beacon 2000 Fluorescence Polarization System, and a ISS PC1 Spectrofluorometer.