The Department of Structural and Chemical Biology houses internationally respected research programs focusing on the molecular electrophysiology of cell excitability and cardiology, and on experimental and computational investigations of the structure, function and regulation of macromolecules in transcription and translation, signal transduction, stem cell development, cancer and aging. The research by the Departmental faculty is directed at the understanding of the molecular basis of human biology and disease, with research strengths in molecular and cell biology and biophysics, structural biology, computational biology, and target structure-based small molecule design. Major approaches include biochemistry and biophysics of proteins/nucleic acids/membranes, chemical biology of small molecules, electrophysiology, molecular biology, cryo-electron microscopy, NMR spectroscopy, X-ray crystallography, computational modeling and simulation.