Selected Student Publications

The following is a sample of recent publications in various scientific journals co-authored by students from Mount Sinai’s Graduate School of Biomedical Sciences.

null1. Miguel Fribourg
Miguel graduated in 2011 after working in the laboratory of Dr. Vladimir Brezina and Dr. Diomedes E. Logothetis. Miguel’s research focused on the mechanism of action of antipsychotic drugs targeting a G protein-coupled receptor complex involved in schizophrenia.

Why Mount Sinai: "Coming from a non-biological background (I have an engineering background), I was excited to see that the Graduate School was open to candidates with an interest in multidisciplinary research. Research is about challenging ourselves to see things from a different perspective, and having a different background helps.  One of the things I like the most about Mount Sinai is the diversity in nationalities. Exchanging ideas with people with different backgrounds that have studied in different countries fosters good science."

Selected Publication:

Cell. 2011 Nov 23;147(5):1011-23.
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE.
Department of Structural and Chemical Biology, Icahn School of Medicine, New York, NY 10029, USA.

 


null2. Lauren Friedman
Lauren is a 6th-Year PhD student working in the laboratory of Dr. Deanna Benson, seeking to understand how the failure of a cellular waste-removal system may play a role in the pathological features associated with Parkinson's disease.

Why Mount Sinai:  "Since the graduate school is part of a medical center, graduate school students have the opportunity to directly interact with clinicians treating the diseases that we study.  The graduate school recently started offering a Clinical Neuroscience class.  This class provided me the unique opportunity not only to meet with patients at the hospital, but also to observe their exams and ask them questions about their symptoms."

How Mount Sinai aids students in publishing:  "The library provides a few basic workshops on how to use reference and imaging software, but the most valuable resource has been feedback from different faculty members."

Selected Publication:

J Neurosci. 2012 May 30;32(22):7585-93.
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.

Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, Yue Z.
Department of Neurology, Friedman Brain Institute, Icahn School of Medicine, New York, NY 10029, USA.


null3. Michael Green

Michael is a MD/PhD student who did his doctoral dissertation in the laboratory of Dr. Hans Snoeck.  Michael focused on discovering new ways to transform stem cells into mature cell types.

Why Mount Sinai: "Mount Sinai is unique because of the open collaborative environment it fosters. Having worked in many institutes, I really appreciate the intellectual and reagent exchange here. Besides the sense of community, I really like that Mount Sinai is filled with creative, innovative people who have a lot of positive energy."

How Mount Sinai aids students in publishing: "Mount Sinai helps its students in so many ways—from the many collaborative principle investigators (PIs), to the readily available core facilities, to the dedicated teaching facility. It really facilitates students’ educations, while immersing them in top-notch research environments that help them publish papers."

Selected Publication:

Nat Biotechnol. 2011 Mar;29(3):267-72. Epub 2011 Feb 27.
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

Green MD, Chen A, Nostro MC, d'Souza SL, Schaniel C, Lemischka IR, Gouon-Evans V, Keller G, Snoeck HW.
Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Icahn School of Medicine, New York, New York, USA.


null4. Amanda Huber
Amanda graduated in 2011 after working in the laboratory of Dr. Yaron Tomer.  Her research focus was studying the etiology of autoimmune thyroid disorders.

Why Mount Sinai: "Its collaborative nature in the immunology department. If I didn’t know how to do a technique, I was able to find someone that was an expert in it that could teach me. Everyone made me feel very welcome, even though I was a transfer student."

Selected Publication:

J Immunol. 2012 Sep 15;189(6):3043-53. Epub 2012 Aug 10.
Genetically Driven Target Tissue Overexpression of CD40: A Novel Mechanism in Autoimmune Disease.

Huber AK, Finkelman FD, Li CW, Concepcion E, Smith E, Jacobson E, Latif R, Keddache M, Zhang W, Tomer Y.
Division of Endocrinology, Icahn School of Medicine, New York, NY 10029.


null5. Jennifer Miller
Jennifer is a 6th-Year MD/PhD student who completed her doctoral training in the laboratory of Dr. Miriam Merad.  She focused on the transcriptional regulation of the hematopoietic mononuclear phagocytic lineage, specifically, dendritic cells and macrophages as well as their precursors.

Why Mount Sinai: "I think the close interaction between physicians in the clinic and scientists at the bench makes research at Mount Sinai particularly translational and thus extraordinarily relevant in today's medical field. I love the collaborative spirit of Mount Sinai and its faculty. I would not have been able to publish my paper if it were not for the countless conversations with my fellow labmates, the Immunology Department members, and members of other Sinai Institutes including the Institutes for Genomics and Multiscale Biology."  

How Mount Sinai aids students in publishing: "The main determinant in my publications was my PI. She is a prolific mentor and scientist.  I also found throughout my PhD that I could contact almost any physician or scientist here at Mount Sinai for help with my project."

Selected Publication:

Nat Immunol. 2012 Jul 15;13(9):888-899. doi: 10.1038/ni.2370. Epub 2012 Jul 15.
Deciphering the transcriptional network of the dendritic cell lineage.

Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M.
Collaborators (46)
Gautier EL, Jakubzick C, Randolph GJ, Best AJ, Knell J, Goldrath A, Miller J, Brown B, Merad M, Jojic V, Koller D, Cohen N, Brennan P, Brenner M, Shay T, Regev A, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S, Jianu R, Laidlaw D, Collins J, Narayan K, Sylvia K, Kang J, Gazit R, Rossi DJ, Kim F, Rao TN, Wagers A, Shinton SA, Hardy RR, Monach P, Bezman NA, Sun JC, Kim CC, Lanier LL, Heng T, Kreslavsky T, Painter M, Ericson J, Davis S, Mathis D, Benoist C.
1] Immunology Institute, Icahn School of Medicine, New York, New York, USA. [2] Department of Oncological Sciences, Icahn School of Medicine, New York, New York, USA.


null6. Natalie Pica
Natalie is a MD/PhD student, who completed her PhD in May and expects to complete her MD in 2014.  She completed her thesis work in the laboratory of Dr. Peter Palese, researching Influenza virus vaccinology, including the induction of broadly cross-reactive influenza virus antibodies.

Why Mount Sinai: "Scientific training at an academic medical center provides a unique opportunity for students to study clinically relevant questions that have translational focus.  As such, Mount Sinai is a very special place in which to train.  In particular, I was extremely fortunate to have worked with a world-renowned investigator in a department that is recognized for excellence in influenza virus research."

How Mount Sinai aids students in publishing: "Because Mount Sinai is not affiliated with an undergraduate institution, graduate students can be one of the primary focuses for the principal investigator.  As a result, students can receive incredible training and numerous opportunities to publish."

Selected Publication:

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2573-8. Epub 2012 Jan 30.
Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses.

Pica N, Hai R, Krammer F, Wang TT, Maamary J, Eggink D, Tan GS, Krause JC, Moran T, Stein CR, Banach D, Wrammert J, Belshe RB, García-Sastre A, Palese P.
Department of Microbiology, Emerging Pathogens Institute, Icahn School of Medicine, New York, NY 10029, USA.


null7. Ajay Ummat
Ajay is a 6th-Year PhD student working in the laboratory of Dr. Aneel Aggarwal, researching DNA replication and DNA repair to understand the mechanisms behind these important biological processes.

Why Mount Sinai: "Mount Sinai has a very vibrant, closed knit research community with great facilities and a focus on relevant biologically important research.  Mount Sinai has a good combination of laboratories in different areas of Biophysics. Specifically, Dr. Aggarwal's work was very interesting to me and offered a great learning environment."

How Mount Sinai aids students in publishing: "The environment is very encouraging and supportive of student research. Strong support of mentors and access to all the facilities makes this process feasible."

Selected Publication:

Nat Struct Mol Biol. 2012 May 6;19(6):628-32. doi: 10.1038/nsmb.2295.
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy.

Ummat A, Rechkoblit O, Jain R, Roy Choudhury J, Johnson RE, Silverstein TD, Buku A, Lone S, Prakash L, Prakash S, Aggarwal AK.
Department of Structural and Chemical Biology, Icahn School of Medicine, New York, New York, USA.