Structural/Chemical Biology and Molecular Design
Mount Sinai’s training area in Structural/Chemical Biology and Molecular Design (SMD) is at the interface between two naturally allied fields: Structural Biology and Chemical Biology. The former is an established area of modern biology with an extensive history at Mount Sinai, which is focused on the elucidation of macromolecular structure and function through X-ray crystallography, NMR spectroscopy, cryo-electron microscopy, mass-spectrometry and biophysical studies of single molecules. The latter is an emerging discipline encompassing traditional aspects of medicinal and bioorganic chemistry, biochemistry and molecular biophysics, enhanced by recent advances in genetics, genomics and proteomics.
SMD integrates experimental and computational methods, so that experimentation is guided by theory and vice versa; molecular computational biology and bioinformatics are therefore strongly represented in SMD.
SMD students come from diverse training backgrounds including mathematics, physics, computer science, engineering, chemistry, biochemistry, genetics and many more. This diversity is further enhanced by the multidisciplinary nature of research projects and training faculty. Many of our trainees come from quantitative backgrounds and get their first rigorous exposure to biological research during their PhD training at Mount Sinai. Conversely, students with a more biological background get the opportunity to obtain rigorous training in biophysical, chemical, and computational approaches to biological research. This multidisciplinary training in basic science is complemented by a strong biomedical research tradition at Mount Sinai.
Graduate School of Biomedical Sciences
Iban Ubarretxena, PhD is Associate Professor, Department of Structural and Chemical Biology. His laboratory investigates the role of eukaryotic membrane proteins in cellular processes and in disease.
Marta Filizola, PhD is Professor, Department of Structural and Chemical Biology. Her laboratory uses computational biophysics methods to investigate biological processes mediated by membrane protein systems.