Laboratories

As a student in our Genetics and Genomic Sciences (GGS) Graduate Training Program, you will devote a significant portion of your time to research. Explore our laboratories and learn about our investigators.

Lab NameDescription
Bakel Laboratory Applying novel genomics technologies to fundamental problems in infectious disease to understand host pathogen interactions and the molecular basis of evolution and transmission of bacteria and viruses
Bashir Laboratory Investigating various complications in genomic architecture, using various techniques including advanced genome sequencing
Bjorkegren Laboratory Using multi-modal big data analysis to create reliable network models of human biology and disease, with a focus on cardiovascular disease
Branch Laboratory Investigating Hepatitis C virus, development of hepatocellular carcinoma (liver cancer), and the immunobiology of the human liver
Brown Laboratory Identifying factors that control immunity and tolerance, and utilizing this information for developing therapeutic strategies that can direct antigen-specific immune responses for treating cancer and autoimmune disease. Also developing new translational technologies for improving emerging therapies and biomedical discovery.
Bunyavanich Lab

The Bunyavanich Lab combines tools in epidemiology, genomics, and sequence analysis to study asthma and allergic diseases in human cohorts.

Research Categories: Complex disease genetics, Bioinformatics, computational biology and network modeling, Immunology and infectious disease

Celebi Laboratory Exploring the molecular genetics of melanoma
Chang Laboratory Focusing on dissecting the multi-scale molecular interaction networks and signaling pathways in human diseases, such as cancer, aging-related disorder, Alzheimer's and psychiatric disease
Rong Chen Laboratory Identifying novel diagnostics, therapeutics, and precision medicine for rare diseases, cancer, Alzheimer's disease, obesity, and metabolic diseases by integrating millions of genomes with medical records
Chess Laboratory Studying unusual mechanisms involved in regulating gene expression
Cho Laboratory Investigating genetic and immunologic factors associated with Crohn’s Disease and ulcerative colitis (inflammatory bowel diseases)
Clemente Laboratory Developing methods to understand microbiome contribution to human health
Desnick Research Improving therapies for genetic diseases such as Fabry disease and porphyria
Dudley Laboratory Focusing on translational and biomedical informatics approaches to address critical challenges in systems medicine
Faith Laboratory Applying experimental and computational tools to understand interactions between diet, the microbiota and health, with an emphasis on Inflammatory Bowel Disease (IBD)
Fang Laboratory Studying epigenomics and transcriptomics of human diseases, including novel forms of epigenetic marks and where are they on the genome, cell-to-cell heterogeneity, and their functions in health and diseases (stem cells, infection, brain, cancers), as well as epigenetic marks for medical impact
Gelb Laboratory The Gelb research group is focused on disease gene discovery using genomic techniques and characterization of the biological roles of such genes in disease pathogenesis. The focus of the laboratory currently is on those traits that are associated with heart malformations.
Goate Laboratory Researching the molecular basis of Alzheimer's disease, frontotemporal dementia and alcohol addiction to identify novel targets for therapeutic development, using genetic and genomic approaches to identify susceptibility alleles, including genome wide association studies and whole genome/exome sequencing
Gumus Laboratory Developing and applying computational methods and tools to define and implement genomics-based precision medicine approaches to identify drivers of pathogenesis and drug targets for cancer precision medicine. Our current laboratory focus is on cancers of the lung, colon, pancreas and the ovaries
Hajjar Laboratory (Wiener Family Cardiovascular Research Laboratories) Concentrating on gene therapy for heart failure and other cardiovascular diseases
Hanson Laboratory

Molecular engineering, cancer vaccines, cancer sensors, synthetic biology, molecular sensors, aptamer sensors, imaging, biophysics, nanotech, neuroscience, connectome imaging, bioinformatics, genomics, personalized medicine, stratified medicine, biomarker development, and big data.

Research Categories: Cancer, Bioinformatics, computational biology and network modeling, Drug discovery, drug development and therapy
Hao Laboratory Studying human disease through statistical genetics.
Sander Houten Research Focusing on the pathophysiology of inborn errors of metabolism aiming to improve therapeutic strategies
Ioannou Laboratory Researching Niemann-Pick disease; NPC1L1; and lysosomal proteomics/lipidomics
Jabs Laboratory (Ethylin Wang Labs) Elucidating the molecular pathogenesis of human malformation disorders including craniosynostosis, oral clefting, limb disorders, and neural tube defects using craniofacial and stem cell biology, and animal model systems
Karr Laboratory Researching to understand and reverse engineer the complexity of biology to enable (1) personalized and predictive medicine and (2) rational bioengineering. Focusing on answering key questions on cell growth and minimal gene complement necessary to support human life
Kasarskis Laboratory Exploring new therapeutics and diagnostics, focusing on developing and applying technology to several areas including pathogen surveillance, pharmacogenomics, and the genetics of sleep
Kenny Laboratory Analyzing human genetic variation to address fundamental questions in biology, medicine, and anthropology with the ultimate goals of producing better outcomes in medical genomics and ameliorating health disparities.
Klein Laboratory Determining how inherited genetic factors contribute to the risk of cancer using a combination of computational and experimental approaches including genetic epidemiology, functional genomic profiling, and targeted manipulations of cancer cell line models
Laserson Laboratory

The Laserson Lab develops high-throughput, data-intensive assays for studying the adaptive immune system.

Research Categories: Drug discovery, drug development and therapy, Immunology and infectious disease

Loos Laboratory Studying genes that increase risk of obesity and related traits to gain insight into the biology that controls body weight and to learn how lifestyle can reduce one's genetic susceptibility
Ma'ayan Laboratory Applying computational and mathematical methods to study the complexity of regulatory networks in mammalian cells
Martignetti – Ovarian Cancer Translational Research Group Investigating: 1) markers for early detection and prevention of ovarian cancer by identifying molecules that tumors secrete possibly signaling early-stage tumor formation or treatment response, and 2) potential therapeutic targets and genetic markers associated with disease recurrence and pre-cancer risk
Paisan-Ruiz Laboratory Elucidating and understanding the genetic etiology of movement disorders such as Parkinson's disease, Parkinsonism, and essential tremor to gain a better understanding of disease pathogenesis and novel targets for drug developing
Pandey Laboratory Developing and applying computational methods to biomedical, genomic and environment data for building predictive and network models of complex biological processes and diseases.
Peter Laboratory Focusing on the genetics, genomics and the microbiome studies of Inflammatory Bowel Disease, obesity, diabetes, and cardiovascular disease, including pharmacogenomics, to gain a better understanding of the interplay between the genetic and environmental factors involved in the pathogenesis of complex diseases
Pinto Laboratory Identifying genes and biological pathways involved in various neurodevelopmental disorders
Purcell Laboratory Investigating the genetic basis of neuropsychiatric disease
Roussos – Functional Neurogenomics Laboratory Exploring the genetics of regulation of gene expression in neuropsychiatric diseases.
Sachidanandam Laboratory Focusing on two research areas: TCR repertoire monitoring and mitochondrial genetics, developing novel, deep sequencing techniques to study them. We also collaborate with some microbiology labs to understand disease progression from a genomic perspective
Schadt Laboratory – Icahn Institute for Genomics & Multiscale Biology, Dept. of Genetics and Genomic Sciences Using multiscale approaches to investigate, analyze, and understand human biology and the root causes of human disease
Schuchman Laboratory - Genetic Disease Foundation Studying the biology of lysosomal enzymes, genes and diseases to develop novel therapies for lysosomal storage disorders
Scott Laboratory Studying the genetic determinants of drug response variability and the development of next-generation sequencing methods for pharmacogenomic research and clinical testing
Sharp Laboratory Utilizing new and novel technologies to study epigenetic modifications, DNA methylation and gene expression to uncover patterns associated with disease
Sklar Laboratory of Psychiatric Genomics Defining the genetic architecture of the two most severe and heritable adult psychiatric disorders, bipolar disorder (BD) and schizophrenia (SCZ)
Stahl Lab

The Stahl laboratory is engaged in complex trait genetics and the inference of genetic architecture, through analysis of both common and rare variant genomic data, and through integration with other genomic and phenotypic data.

Research Categories: Human genetics, Complex disease genetics, Genetics of neurological disease, Genomics/Epigenomics, Bioinformatics, computational biology and network modeling

Stewart Laboratory Translating human pancreatic beta cell biology into beta into beta cell regeneration for diabetes therapy
Tu Laboratory Using network modeling to understand processes involved in aging and examining their connections with various diseases, and to prioritize the key pathways driving aging and diseases.
Watanabe Laboratory Studying transcriptional regulation of lung cancer through single cell and epigenomic technologies
Xu Laboratory Investigating how the network of transcription factors/chromatin regulators and gene interactions drive progenitor cell development, maintenance, and regeneration in the inner ear and kidney. We seek new insight into the genetic networks that underlie congenital neurosensory deficits and renal diseases.
Zhang Multiscale Network Modeling Laboratory Focusing on construction, characterization and validation of multiscale biological networks, from large-scale genomic, genetic, epigenetic, proteomic and clinical data in complex human diseases
Zhao Laboratory Exploring genetic, epigenetic, proteomic and clinical data in complex human diseases
Zhu Laboratory Focusing on dissecting molecular mechanisms underlying complex phenotypes through analyzing large-scale high-throughput data