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Alex Manini

  • ASSOCIATE PROFESSOR Emergency Medicine
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Education

  • B.S., Massachusetts Institute of Technology

  • Brigham & Women's Hospital / Massachusetts General Hospital Harvard Medical School
    Emergency Medicine

  • Brigham & Women's Hospital / Massachusetts General Hospital Harvard Medical School

  • M.S., New York University

  • Bellevue Hospital Center - NYU School of Medicine
    Medical Toxicology

  • MD, UCSF School of Medicine

Biography

    Dr. Manini is Associate Professor of Emergency Medicine at the Icahn School of Medicine at Mount Sinai in New York City. He practices at Elmhurst Hospital Center with board certification in Emergency Medicine and Medical Toxicology. He received his undergraduate degree in biology from MIT, followed by an MD from UCSF and MS in clinical investigation at NYU. He trained in emergency medicine at the Harvard Affiliated Emergency Medicine Residency at Massachusetts General Hospital and Brigham and Women's Hospital in Boston, MA. He completed fellowship in medical toxicology at NYU/Bellevue in New York City.

    Dr. Manini has authored over 50 peer-reviewed publications and his current research interests include clinical studies to characterize and evaluate adverse cardiovascular events following acute drug overdose. In 2011 he was named the Young Investigator of the Year by the Society for Academic Emergency Medicine (SAEM) and in 2013 he was voted Young Investigator of the Year by the European Association of Poison Centres and Clinical Toxicologists (EAPCCT).  He has received research grant support from the National Institutes of Health, National Institute on Drug Abuse, National Center for Advancement of Translational Sciences, and the City of New York.

     

    Please click here to access Dr. Manini's biosketch:

     

Awards

  • 2014 -
    NIH Study Section Member, CEBRA (Cutting Edge Basic Research Awards)

  • 2014 -
    Top Consultant, Annals of Emergency Medicine

  • 2013 -
    Senior Reviewer
    Annals of Emergency Medicine

  • 2013 -
    Fellow of the American College of Medical Toxicology
    FACMT

  • 2013 -
    NIH Early Career Reviewer (ECR), Center for Scientiic Review

  • 2013 -
    Young Investigator Award WINNER, XXXIII International Congress
    EAPCCT

  • 2011 -
    The Dr. Harold and Golden Lamport Reseach Award
    Mount Sinai School of Medicine

  • 2011 -
    Young Investigator of the Year
    Society of Academic Emergency Medicine (SAEM)

Research

Adverse Cardiovascular Events from Drug Overdose

In 2014, Dr. Manini received a five-year Research Project Grant (R01) from the National Institute on Drug Abuse at the NIH. The award involves collaboration between Mount Sinai investigators in neuroscience, cardiology, epidemiology, emergency medicine, and medical toxicology, along with co-investigators from the NYU School of Medicine and the Toxicology Investigators’ Consortium, a national registry sponsored by the American College of Medical Toxicology. Clinical studies launched by the R01 will test a broad array of risk prediction instruments, laboratory biomarkers, and opioid receptor gene polymorphisms, with the goal to produce clinical tools to individualize prevention strategies for curtailing the national rise in drug overdose fatality.

In 2014, Dr. Manini was appointed Site PI of the NIDA National Early Warning System Network (iN3). The study is funded by an NIH High Priority Short Term Project (R56) from the National Institute on Drug Abuse. The goal of the study is to identify new episodes of emerging drug use nationally to advance drug surveillance from a reactive to anticipatory science.

In 2009, Dr. Manini received a Career Development Grant Award (K23) from the National Institute on Drug Abuse at the NIH. Mentored by David Vlahov, PhD and Lynne Richardson, MD, Dr. Manini studied clinical risk factors for adverse cardiovascular events in drug overdose emergencies

 

 

Publications

Manini AF, Skolnick A, Nelson LS, Slater W, Hoffman RS. Electrocardiographic predictors of adverse cardiovascular events in suspected poisoning.. J Med Toxicol 2010; 6(2): 106-15.

Manini AF, Kumar A, Olsen D, Vlahov D, Hoffman RS. Utility of serum lactate to predict drug overdose fatality. Clin Toxicol ((Phila) 2010; 49(8): 730-6.

Manini AF, Nelson LS, Olsen D, Vlahov D, Hoffman RS. Medical examiner and medical toxicologist agreement on cause of death. Foresic Sci Int 2011; 206((1-3)): 71-6.

Manini AF, Nelson LS, Hoffman RS. Prognostic utility of serum potassium in chronic digoxin toxicity: a case-control study. Am J Cardiovasc Drugs 2011; 11(3): 173-8.

Geib AJ, Liebelt E, Manini AF. Toxicology Investigators' Corsortium (ToxlC) . Clinical experience with intravenous lipid emulsion for drug-induced cardiovascular collapse. J Med Toxicol 2012; 8(1): 10-14.

Manini AF, Nelson LS, Stimmel B, Vlahov D, Hoffman RS. Incidence of adverse cardiovascular events in adults following drug overdose. Acad Emerg Med 2012; 19(7): 843-849.

Manini AF, Jacobs MM, Vlahov D, Hurd YL. Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. J Med Toxicol 2013; 9(2): 148-54.

Hoffmann U, Nagurney JT, Moselewski F, Pena A, Ferencik M, Chae CU, Cury RC, Butler J, Abbara S, Brown DF, Manini A, Nichols JH, Achenbach S, Brady TJ. Coronary multidetector computed tomography in the assessment of patients with acute chest pain. Circulation 2006 Nov; 114(21).

Smith SW, Manini AF, Szekely T, Hoffman RS. Bedside detection of urine beta-hydroxybutyrate in diagnosing metabolic acidosis. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2008 Aug; 15(8).

Manini AF, Ilgen J, Noble VE, Bamberg F, Koenig W, Bohan JS, Hoffmann U. Derivation and validation of a sensitive IMA cutpoint to predict cardiac events in patients with chest pain. Emergency medicine journal : EMJ 2009 Nov; 26(11).

Manini AF, Hoffman RS, McMartin KE, Nelson LS. Relationship between serum glycolate and falsely elevated lactate in severe ethylene glycol poisoning. Journal of analytical toxicology 2009 Apr; 33(3).

Manini AF, Nelson LS, Skolnick AH, Slater W, Hoffman RS. Electrocardiographic predictors of adverse cardiovascular events in suspected poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology 2010 Jun; 6(2).

Manini AF, Kumar A, Olsen D, Vlahov D, Hoffman RS. Utility of serum lactate to predict drug-overdose fatality. Clinical toxicology (Philadelphia, Pa.) 2010 Aug; 48(7).

Manini AF, Nelson LS, Olsen D, Vlahov D, Hoffman RS. Medical examiner and medical toxicologist agreement on cause of death. Forensic science international 2011 Mar; 206(1-3).

Leung L, Wilson D, Manini AF. Fatal toxicity from symptomatic hyperlactataemia: a retrospective cohort study of factors implicated with long-term nucleoside reverse transcriptase inhibitor use in a South African hospital. Drug safety 2011 Jun; 34(6).

Manini AF, Nelson LS, Hoffman RS. Prognostic utility of serum potassium in chronic digoxin toxicity: a case-control study. American journal of cardiovascular drugs : drugs, devices, and other interventions 2011 Jun; 11(3).

Geib AJ, Liebelt E, Manini AF. Clinical experience with intravenous lipid emulsion for drug-induced cardiovascular collapse. Journal of medical toxicology : official journal of the American College of Medical Toxicology 2012 Mar; 8(1).

Manini AF, Nelson LS, Stimmel B, Vlahov D, Hoffman RS. Incidence of adverse cardiovascular events in adults following drug overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2012 Jul; 19(7).

Manini AF, Jacobs MM, Vlahov D, Hurd YL. Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. Journal of medical toxicology : official journal of the American College of Medical Toxicology 2013 Jun; 9(2).

Manini AF, Stimmel B, Vlahov D. Racial susceptibility for QT prolongation in acute drug overdoses. Journal of electrocardiology; 47(2).

Shah A, Chisolm-Straker M, Alexander A, Rattu M, Dikdan S, Manini AF. Prognostic use of lactate to predict inpatient mortality in acute gastrointestinal hemorrhage. The American journal of emergency medicine 2014 Jul; 32(7).

Manini AF, Santos C. The impact of the drug overdose epidemic on the mortality of persons with HIV/AIDS. J Clinic Toxicol 2011; SI:004.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Manini did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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