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Alice Huang

  • ASSISTANT PROFESSOR Orthopaedics
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Biography

    Dr. Alice Huang is an Assistant Professor in the Leni and Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai in New York City. Dr. Huang graduated from Barnard College and the School of Engineering and Applied Science at Columbia University with a B.A. in Asian/Middle Eastern Studies and a B.S. in Biomedical Engineering. She then completed her PhD in Bioengineering at the University of Pennsylvania under the guidance of Dr. Robert Mauck. Dr. Huang's graduate research was devoted to the mechanobiology of mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Following the complete of her graduate studies, Dr. Huang was a postdoctoral researcher in Developmental Biology at Shriners Hospital for Children, mentored by Dr. Ronen Schweitzer. Using a variety of genetic models, her postdoctoral work focused on how the coordinated development of the musculoskeletal system during embryogenesis. In 2014, Dr. Huang joined the faculty at Mount Sinai as an Assistant Professor in the Department of Orthopaedics, with a secondary appointment in Developmental and Regenerative Biology. 

Research

Research

Dr. Huang’s research focuses on the molecular and mechanical regulation of stem cell induction and differentiation during fibrous connective tissue healing and regeneration, with particular focus on tendon/ligament and the annulus fibrosis of the spine. The work of her laboratory combines genetic mouse models and the tools of developmental biology with in vitro tissue engineering approaches.  To date, a complete understanding of the cell biology and molecular mechanisms underlying the injury and healing response has been limited, due to a paucity of available markers and tools for these tissues. Dr Huang’s work addresses this area of research, applying genetic mutants that have been implicated in various aspects of fibrous tissue differentiation and development in the context of injury. In the long term, these studies will open new avenues for regenerative therapies. For more information, please visit labs.icahn.mssm.edu/huanglab.

Publications

Huang AH, Riordan TJ, Wang L, Eyal S, Zelzer E, Brigande JV, Schweitzer R. Repositioning forelimb superficialis muscles: tendon attachment and muscle activity enable active relocation of functional myofibers. Developmental cell 2013 Sep; 26(5).

Huang AH, Baker BM, Ateshian GA, Mauck RL. Sliding contact loading enhances the tensile properties of mesenchymal stem cell-seeded hydrogels. European cells & materials 2012; 24.

Huang AH, Farrell MJ, Mauck RL. Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. Journal of biomechanics 2010 Jan; 43(1).

Huang AH, Stein A, Mauck RL. Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Tissue engineering. Part A 2010 Sep; 16(9).

Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine 2010 Apr; 35(8).

Huang AH, Farrell MJ, Kim M, Mauck RL. Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. European cells & materials 2010; 19.

Baker BM, Shah RP, Huang AH, Mauck RL. Dynamic tensile loading improves the functional properties of mesenchymal stem cell-laden nanofiber-based fibrocartilage. Tissue engineering. Part A 2011 May; 17(9-10).

Erickson IE, Huang AH, Sengupta S, Kestle S, Burdick JA, Mauck RL. Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009 Dec; 17(12).

Huang AH, Stein A, Tuan RS, Mauck RL. Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue engineering. Part A 2009 Nov; 15(11).

Erickson IE, Huang AH, Chung C, Li RT, Burdick JA, Mauck RL. Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue engineering. Part A 2009 May; 15(5).

Huang AH, Motlekar NA, Stein A, Diamond SL, Shore EM, Mauck RL. High-throughput screening for modulators of mesenchymal stem cell chondrogenesis. Annals of biomedical engineering 2008 Nov; 36(11).

Huang AH, Yeger-McKeever M, Stein A, Mauck RL. Tensile properties of engineered cartilage formed from chondrocyte- and MSC-laden hydrogels. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008 Sep; 16(9).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Huang is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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