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Alice Huang

  • ASSISTANT PROFESSOR Orthopaedics
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Biography

    Dr. Alice Huang is an Assistant Professor in the Leni and Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai in New York City.

    Dr. Huang graduated from Barnard College and the School of Engineering and Applied Science at Columbia University with a B.A. in Asian/Middle Eastern Studies and a B.S. in Biomedical Engineering.  She then completed her PhD in Bioengineering at the University of Pennsylvania under the guidance of Dr. Robert Mauck.  Dr. Huang’s graduate research was devoted to the mechanobiology of mesenchymal stem cell chondrogenesis for cartilage tissue engineering.  Following the completion of her graduate studies, Dr. Huang was a postdoctoral researcher in Developmental Biology at Shriners Hospital for Children, mentored by Dr. Ronen Schweitzer.  Using a variety of genetic models, her postdoctoral work focused on how the coordinated development of the musculoskeletal tissues (tendon, muscle and cartilage) gives rise to an integrated, functional system during embryogenesis.  In 2014, Dr. Huang joined the faculty at Mount Sinai as an Assistant Professor in the Department of Orthopaedics, with a secondary appointment in Developmental and Regenerative Biology. 

    Research

    Dr. Huang’s research focuses on the molecular and mechanical regulation of stem cell induction and differentiation during fibrous connective tissue healing and regeneration, with particular focus on tendon/ligament and the annulus fibrosis of the spine. The work of her laboratory combines genetic mouse models and the tools of developmental biology with in vitro tissue engineering approaches.  To date, a complete understanding of the cell biology and molecular mechanisms underlying the injury and healing response has been limited, due to a paucity of available markers and tools for these tissues. Dr Huang’s work addresses this area of research, applying genetic mutants that have been implicated in various aspects of fibrous tissue differentiation and development in the context of injury. In the long term, these studies will open new avenues for regenerative therapies.

    Selected Publications

    1. Huang AH, Riordan TJ, Wang L, Eyal S, Zelzer E, Brigande JV, Schweitzer R. "Re-positioning forelimb superficialis muscles: tendon attachment and muscle activity enable active relocation of functional myofibers," 2013, Developmental Cell, 26(5): 544-551.

    2. Huang AH, Baker BM, Ateshian GA, Mauck RL. "Sliding Contact Enhances the Tensile Properties of Mesenchymal Stem Cell-Seeded Hydrogels," 2012, European Cells and Materials, 24:29-45.

    3. Baker BM, Shah R, Huang AH, Mauck RL. "Dynamic Tensile Loading Improves the Functional Properties of MSC-Laden Nanofiber-Based Fibrocartilage," 2011, Tissue Engineering: Part A, 17(9-10):1445-55.

    4. Huang AH, Farrell MJ, Kim M, Mauck RL. "Long-term Dynamic Compressive Loading Improves the Mechanical Properties of Mesenchymal Stem Cell-Laden Hydrogels," 2010, European Cells and Materials, 19:72-85.

    5. Huang AH, Stein A, Mauck RL. "Evaluation of the Complex Molecular Topography of Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering," 2010, Tissue Engineering: Part A, 16(9):2699-708.

    6. Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. "Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement," 2009, Spine, 35(8):867-73.

    7. Huang AH, Farrell MJ, Mauck RL. "Mechanics and Mechanobiology of Mesenchymal Stem Cell-Based Engineered Cartilage," 2010, Journal of Biomechanics, 43(1):128-36.

    8. Erickson IE, Huang AH, Sengupta S, Kestle S, Burdick JA, Mauck RL. "Macromer Density Influences Mesenchymal Stem Cell Chondrogenesis and Maturation in Photocrosslinked Hyaluronic Acid Hydrogels," 2009, Osteoarthritis and Cartilage, 17(12):1639-48.

    9. Huang AH, Stein A, Tuan RS, Mauck RL. "Transient Exposure to TGF-B3 Improves the Mechanical Properties of Mesenchymal Stem Cell-Laden Constructs in a Density Dependent Manner," 2009, Tissue Engineering: Part A, 15(11):3461-72.

    10. Bargman R, Huang A, Boskey AL, Raggio C, Pleshko N. "RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta," 2009, Connective Tissue Research, 51(2):123-31.

    11. Huang AH, Motlekar NA, Stein A, Diamond SL, Shore EM, Mauck RL. "High Throughput Screening for Modulators of Mesenchymal Stem Cell Chondrogenesis," 2008, Annals of Biomedical Engineering, 36(11):1909-21.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Huang is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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