An-Li Wang, PhD
- ASSISTANT PROFESSOR | Psychiatry
PhD, University of Oxford
PhD, University of Pennsylvania
Effect of opioid antagonist treatment on cue reactivity and social cognition
Opioid antagonist treatment has been gaining acceptance as an alternative to opioid maintenance treatment of opioid use disorder in the US and worldwide. Yet, its effect on cue reactivity (an important indicator of relapse) and social cognition such as caregiving remains largely unknown. My colleagues and I used a validated cognitive probe to study the effects of long-acting preparation of an opioid antagonist naltrexone on the brain and behavioral response to baby schema in men and women with chronic opioid use disorder, as well as studied the predictive value of neural activities in respond to drug-related cues to treatment adherence. Our studies provided preliminary data on an understudied aspect of opioid addiction and opioid antagonist treatment response. We found that opioid antagonist treatment modulates the brain fMRI response to drug-related cues and that adherence to treatment can be predicted by the baseline brain fMRI response to drug cues. a. Wang AL, Elman I, Lowen BS, Blady JS, Lynch GK, O’Brien PC and Langleben DD Neural correlates of adherence to extended-release naltrexonepharmacotherapy in heroin dependence. Translational Psychiatry. 2015 Mar 17;5:e531. doi: 10.1038/tp.2015.20. PMCID: PMC4354350. b. Wang AL, Lowen SB, Elman I, Shi ZH, Bouril A, Gur RC and Langleben DD. Sustained opioid antagonism increases striatal sensitivity to baby schema in opioid dependent women. J Subst Abuse Treat, in press c. Langleben DD, Wang AL, Hakun JG, Seelig D, Barndollar RK, Bilker WB, Busch EL, Ruparel K, Gur RC. Poly graph and fMRI in lie detection: a controlled blind comparison using the Concealed Information Test. J Clin Psychiatry, in press.
Neuroscience and public health communications
Televised public service announcement (PSA) or health messages are a key component of health campaigns promoting desired behaviors in general public. However, their impact in the field has been modest at best, despite strong theoretical basis and extensive cross-sectional surveys. Thus, better understanding in the neurobiological mechanisms underlying the brain processing of persuasive information and more efficient ways to evaluate the effectiveness of these messages are urgently needed. I was among the first to apply neuroscience knowledge and methodology to study public health communications. Using functional magnetic resonance imaging (fMRI), I demonstrated that the key health communications concepts of message sensation value and argument strength had brain correlates that predicted the impact of anti-smoking PSAs on smoking behavior, indexed by the urine cotinine level. The high translational significance of this study was highlighted in the NIDA Notes and the Nature Reviews Neuroscience. Also, I conducted electroencephalograph (EEG) and fMRI studies investigating the neurobiological effects of emotional graphic cigarette warning labels (GWLs) on cognition and behavioral correlates of smoking in adult smokers, as the debate surrounding graphic warnings was evolving. These findings provided the first biological evidence supporting that emotional salience is essential to the effectiveness of GWLs and is likely to influence the future regulation of tobacco product packaging in the US. c. Wang AL, Ruparel K, Loughead JW, Strasser AA, Blady SJ, Lynch KG, Romer D, Cappella JN, Lerman C and Langleben DD (2013) Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements. J Neurosci. 33(17):7420-7. PMCID: PMC3773220. d. Wang AL, Romer D, Elman I, Turetsky BI, Gur RC & Langleben DD (2013) Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues. Addict. Biol. 2015 Mar;20(2):368-76. doi: 10.1111/adb.12117. Epub 2013 Dec 15. PMCID: PMC4492684. e. Wang AL, Lowen BS, Romer D, Jagannathan K, Langleben, DD. Emotional reaction facilitates the brain and behavioral impact of graphic cigarette warning labels in smokers. Tobacco Control, 2015 Jan 6. pii: tobaccocontrol-2014-051993. doi: 10.1136/tobaccocontrol-2014-051993. PMCID: PMC4495960. f. Wang AL, Lowen SB, Shi ZH, Bissey B, Metzger DS and Langleben DD. Targeting modulates audiences’ brain and behavioral responses to safe sex video ads. Social Cognitive and Affective Neuroscience, 11(10):1650-7. doi: 10.1093/scan/nsw070. PMCID: PMC5040911.
Pain perception and functional significance of sensory ERPs in healthy subjects
When ERPs are elicited by pairs or trains of stimuli delivered at short inter‐stimulus intervals (ISIs), the magnitude of the ERP elicited by the repeated stimuli is markedly reduced, a phenomenon known as response decrement. While the interval between two consecutive stimuli becomes longer, the reduced response is recovered. Thus, this phenomenon has been traditionally interpreted in terms of neural refractoriness of generators of ERPs (“neural refractoriness hypothesis”). A series of my ERP studies, however, challenge this neural refractoriness hypothesis by manipulating the preceding events of the eliciting stimulus. a. Wang AL, Mouraux A, Liang M, Iannetti GD. (2008) The enhancement of the N1 wave elicited by sensory stimuli presented at very short inter-stimulus intervals is a general feature across sensory systems. Plos one 3(12):e3929. PMCID: PMC2597742 b. Wang AL, Mouraux A, Liang M, Iannetti GD. (2010) Stimulus novelty, and not neural refractoriness, explains the repetition suppression of laser-evoked potentials. J Neurophysiol 104(4):2116-24. doi: 10.1152/jn.01088.2009 PMID: 20592123
Wang AL, Mouraux A, Liang M, Iannetti GD. The enhancement of the N1 wave elicited by sensory stimuli presented at very short inter-stimulus intervals is a general feature across sensory systems. PloS one 2008; 3(12).
Wang AL, Mouraux A, Liang M, Iannetti GD. Stimulus novelty, and not neural refractoriness, explains the repetition suppression of laser-evoked potentials. Journal of neurophysiology 2010 Oct; 104(4).
Wang AL, Ruparel K, Loughead JW, Strasser AA, Blady SJ, Lynch KG, Romer D, Cappella JN, Lerman C, Langleben DD. Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr; 33(17).
Seelig D, Wang AL, Jagannathan K, Jaganathan K, Loughead JW, Blady SJ, Childress AR, Romer D, Langleben DD. Low message sensation health promotion videos are better remembered and activate areas of the brain associated with memory encoding. PloS one 2014; 9(11).
Romer D, Jamieson PE, Bushman BJ, Bleakley A, Wang A, Langleben D, Jamieson KH. Parental desensitization to violence and sex in movies. Pediatrics 2014 Nov; 134(5).
Wang AL, Romer D, Elman I, Turetsky BI, Gur RC, Langleben DD. Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues. Addiction biology 2015 Mar; 20(2).
Wang AL, Elman I, Lowen SB, Blady SJ, Lynch KG, Hyatt JM, O'Brien CP, Langleben DD. Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence. Translational psychiatry 2015 Mar; 5.
Wang AL, Lowen SB, Romer D, Giorno M, Langleben DD. Emotional reaction facilitates the brain and behavioural impact of graphic cigarette warning labels in smokers. Tobacco control 2015 May; 24(3).
Shi Z, Wang AL, Langleben DD. Playing it safe: a video game probing the relationship between addiction, gender, and avoidance. The Journal of clinical psychiatry 2016 Mar; 77(3).
Langleben DD, Hakun JG, Seelig D, Wang AL, Ruparel K, Bilker WB, Gur RC. Polygraphy and Functional Magnetic Resonance Imaging in Lie Detection: A Controlled Blind Comparison Using the Concealed Information Test. The Journal of clinical psychiatry 2016 Oct; 77(10).
Wang AL, Lowen SB, Shi Z, Bissey B, Metzger DS, Langleben DD. Targeting modulates audiences' brain and behavioral responses to safe sex video ads. Social cognitive and affective neuroscience 2016 Oct; 11(10).
Shi Z, Wang AL, Aronowitz CA, Romer D, Langleben DD. Individual differences in the processing of smoking-cessation video messages: An imaging genetics study. Biological psychology 2017 Sep; 128.
Wang AL, Lowen SB, Elman I, Shi Z, Fairchild VP, Bouril A, Gur RC, Langleben DD. Sustained opioid antagonism modulates striatal sensitivity to baby schema in opioid use disorder. Journal of substance abuse treatment 2018 Feb; 85.