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Andreas Plaitakis

  • SENIOR FACULTY Neurology
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  • Neurology, American Board of Psychiatry and Neurology

Clinical Focus


  • MD, University of Athens

  • Internship, Internal Medicine
    Long Island College Hospital

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Residency, Neurology
    Mount Sinai Hospital


    Dr. Andreas Plaitakis is currently Professor of Neurology at Mount Sinai School of Medicine in New York. He holds an M.D. and Ph.D. degree from the University of Athens Greece. He was trained in Internal Medicine and in Neurology at Mount Sinai Hospital, where he also completed his NIH post-doctoral fellowship in Neurochemistry. He then joined the Mount Sinai faculty and rose through the ranks to Professor. After working at Mount Sinai for over 20 years, he became Chairman of the Department of Neurology at the newly established University of Crete, where for a decade, he also served as Dean of Graduate studies and Director of the Graduate Program in Neuroscience. Recently, he returned to Mount Sinai joining again the Neurology faculty.

    Dr. Plaitakis has been the principal investigator of research projects funded by NIH for almost two decades. He has published over 150 original articles and book chapters, and two textbooks. He has been an invited speaker at many National and International Meetings. He is an elected member of the American Neurologic Association.

    All these years, Dr. Plaitakis divided his time between Clinical Neurology and Basic Research. He has made original observations that linked metabolic abnormalities to human degenerative neurological disorders (Plaitakis, et al. Science, 1982). His observations on glutamate alterations in Amyotrophic Lateral Sclerosis was the rationale behind the use of Riluzole, a glutamate-modifying agent, for treating this devastating disorder, the only effective treatment that is currently available.

    At thebasic Science level, his team cloned and characterized human proteins involved in the metabolism and transport of glutamate, a major excitatory neurotransmitter involved in a multitude of normal brain functions and in neurodegenerative processes. They also elucidated the evolutionary steps by which a novel glutamate-metabolizing enzyme acquired unique properties and neuron-specific expression that may have contributed to traits, such as cognitive function, unique to humans.

    Dr. Plaitakis also maintains a special interest in the clinical aspects and pathogenesic mechanisms of movement disorders (Parkinson’s disease, etc), dementia and Multiple Sclerosis (MS). He and his co-investigators identified environmental factors contributing to the rising incidence of MS among females. They also detected brain hemodynamic changes at the earliest stages of MS that correlate with cognitive dysfunction. In addition, he is dedicated to the care of patients with diverse neurologic conditions that fall within the full spectrum of general neurology.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Plaitakis has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at Patients may wish to ask their physician about the activities they perform for companies.

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