Photo of Andrew Shin

Andrew Shin

  • INSTRUCTOR Medicine, Endocrinology, Diabetes and Bone Disease
Print ProfilePrint Profile

Research

We are interested in studying how brain controls energy metabolism. In particular, my current grant focuses on examining the role of insulin in the brain and how it regulates branched-chain amino acid (BCAA) metabolism. This has a high clinical relevance because circulating BCAA levels are elevated in obesity and diabetes and are a sensitive predictor for type 2 diabetes, however the mechanisms behind the impaired BCAA metabolism are not well understood. We have recently demonstrated in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α keto-acid dehydrogenase (BCKDH), the rate-limiting enzyme in the BCAA degradation pathway. Through selective induction of hypothalamic insulin signaling in rats and genetic modulation of brain insulin receptors in mice, we found that that brain insulin signaling is a major regulator of BCAA metabolism by inducing hepatic BCKDH. After confirming that this mechanism is evolutionarily conserved from worms to mammals, we believe that the decreased hepatic BCKDH is a major cause of increased plasma BCAAs, and that hypothalamic insulin resistance may account for impaired BCAA metabolism in obesity and diabetes. We use integrative physiological approaches combined with pharmacological, molecular, and surgical techniques to study the role of brain insulin in the control of nutrient fluxes across different organs like adipose tissue, muscle, and liver.

Publications

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C. Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. Cell metabolism 2014 Oct;.

Shin AC, Berthoud HR. Obesity surgery: happy with less or eternally hungry?. Trends in endocrinology and metabolism: TEM 2013 Feb; 24(2).

Shin AC, Zheng H, Townsend RL, Patterson LM, Holmes GM, Berthoud HR. Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat-fed obese rats. Obesity surgery 2013 Apr; 23(4).

Kasturi BS, MohanKumar SM, Sirivelu MP, Shin AC, Mohankumar PS. Chronic estradiol-17β exposure suppresses hypothalamic norepinephrine release and the steroid-induced luteinizing hormone surge: role of nitration of tyrosine hydroxylase. Brain research 2013 Feb; 1493.

Fargali S, Scherer T, Shin AC, Sadahiro M, Buettner C, Salton SR. Germline ablation of VGF increases lipolysis in white adipose tissue. The Journal of endocrinology 2012 Nov; 215(2).

Berthoud HR, Zheng H, Shin AC. Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery. Annals of the New York Academy of Sciences 2012 Aug; 1264.

Shin AC, Zheng H, Berthoud HR. Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Annals of surgery 2012 Feb; 255(2).

Shin AC, Berthoud HR. Food reward functions as affected by obesity and bariatric surgery. International journal of obesity (2005) 2011 Sep; 35 Suppl 3.

Shin AC, Townsend RL, Patterson LM, Berthoud HR. Liking’ and ‘wanting’ of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. American journal of physiology. Regulatory, integrative and comparative physiology 2011 Nov; 301(5).

Berthoud HR, Lenard NR, Shin AC. Food reward, hyperphagia, and obesity. American journal of physiology. Regulatory, integrative and comparative physiology 2011 Jun; 300(6).

Berthoud HR, Shin AC, Zheng H. Obesity surgery and gut-brain communication. Physiology & behavior 2011 Nov; 105(1).

Shin AC, MohanKumar SM, Sirivelu MP, Claycombe KJ, Haywood JR, Fink GD, MohanKumar PS. Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. International journal of obesity (2005) 2010 Jul; 34(7).

Shin AC, Zheng H, Pistell PJ, Berthoud HR. Roux-en-Y gastric bypass surgery changes food reward in rats. International journal of obesity (2005) 2011 May; 35(5).

Shin AC, Pistell PJ, Phifer CB, Berthoud HR. Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens. Neuroscience 2010 Oct; 170(2).

Zheng H, Townsend RL, Shin AC, Patterson LM, Phifer CB, Berthoud HR. High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation. Brain research 2010 Sep; 1350.

Shin AC, Zheng H, Townsend RL, Sigalet DL, Berthoud HR. Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery. Endocrinology 2010 Apr; 151(4).

Shin AC, MohanKumar SM, Sirivelu MP, Claycombe KJ, Haywood JR, Fink GD, MohanKumar PS. Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. International journal of obesity (2005) 2010 Jul; 34(7).

Zheng H, Shin AC, Lenard NR, Townsend RL, Patterson LM, Sigalet DL, Berthoud HR. Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. American journal of physiology. Regulatory, integrative and comparative physiology 2009 Nov; 297(5).

Shin AC, Zheng H, Berthoud HR. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiology & behavior 2009 Jul; 97(5).

Zheng H, Lenard NR, Shin AC, Berthoud HR. Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. International journal of obesity (2005) 2009 Jun; 33 Suppl 2.

Sirivelu MP, Shin AC, Perez GI, MohanKumar PS, MohanKumar SM. Effect of L-dopa on interleukin-1 beta-induced suppression of luteinizing hormone secretion in intact female rats. Human reproduction (Oxford, England) 2009 Mar; 24(3).

Sirivelu MP, Burnett R, Shin AC, Kim C, MohanKumar PS, MohanKumar SM. Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge. Brain research 2009 Jan; 1248.

Clark KA, Shin AC, Sirivelu MP, Mohankumar SM, Mohankumar PS. Systemic administration of leptin decreases plasma corticosterone levels: role of hypothalamic norepinephrine. Brain research 2008 Feb; 1195.

MohanKumar SM, King A, Shin AC, Sirivelu MP, MohanKumar PS, Fink GD. Developmental programming of cardiovascular disorders: focus on hypertension. Reviews in endocrine & metabolic disorders 2007 Jun; 8(2).

Pasarica M, Shin AC, Yu M, Ou Yang HM, Rathod M, Jen KL, MohanKumar S, MohanKumar PS, Markward N, Dhurandhar NV. Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats. Obesity (Silver Spring, Md.) 2006 Nov; 14(11).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Shin did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

Edit profile in Sinai Central

Address

Atran Berg Laboratory Building Floor 4 Room 23
1428 Madison Avenue
New York, NY 10029


Address

Atran Berg Laboratory Building Floor 4 Room 23
1428 Madison Avenue
New York, NY 10029