Basil G. Hanss
- ASSOCIATE PROFESSOR Medicine, Nephrology
- ASSOCIATE PROFESSOR Medical Education
- ASSOCIATE PROFESSOR Structural and Chemical Biology
B.S., Lewis and Clark College
Ph.D., Tulane University
Dr. Hanss is an Associate Professor at Mt. Sinai School of Medicine with appointments in the Department of Medicine, the Department of Medical Education, and the Department of Structural and Chemical Biology. He received a Bachelor’s Degree from Lewis and Clark College where he studied Biology, and a Ph.D. in Physiology from Tulane University. He spent a year at the National Institutes of Health as a Postdoctoral Fellow before joining the faculty at Mt. Sinai as a Research Assistant Professor in 1996.
Dr. Hanss’s research focuses on discovering the mechanisms by which gene-therapeutic nucleic acids enter the cell. This poorly understood step limits the efficacy of many forms of gene therapy and the knowledge and tools gained from his research will help to overcome this. Dr. Hanss is involved in both classroom teaching and educational administration as well. He has taught medical and graduate students for more than 20 years at several institutions including Tulane University, the MIT/Harvard M.D./Ph.D. training program, and Mt. Sinai School of Medicine. He has been Course Director of the top-rated Medical Physiology course since 2002. In January of 2011, he assumed the role of Director of the Humanities and Medicine Program at Mount Sinai. In the fall of 2011, he was named the founding Director of the new Science and Medicine Program. Most recently, Dr. Hanss was appointed Associate Dean of the Graduate School of Biological Sciences at Mount Sinai.
Characterization of a nucleic acid transporter
The precise molecular mechanism(s) responsible for nucleic acid transport across the plasma membrane are being defined. This research has led to the identification and partial characterization of a plasma membrane protein complex that functions as a highly selective nucleic acid-conducting channel. To date the substrate specificity of the channel has been defined and several channel blockers identified. In addition, three putative channel complex proteins have been cloned. Having now obtained definitive evidence for the role of one of these proteins in channel function future projects focus on definition of the role of the other two proteins. Strategies are being applied to develop a molecular model of nucleic acid transport
Hanss BG, Lewy JE, Vari RC. Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney Int 1994 Jul; 46(1): 48-57.
Rappaport J, Hanss B, Kopp JB, Copeland TD, Bruggeman LA, Coffman TM, Klotman PE. Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. Kidney Int 1995 May; 47(5): 1462-9.
Leal-Pinto E, Hanss B, Klotman PE. Calcium regulation of a cell surface nucleic acid channel. Kidney Int Suppl 1996 Dec; 57: S4-10.
Lipkowitz MS, Klotman ME, Bruggeman LA, Nicklin P, Hanss B, Rappaport J, Klotman PE. Molecular therapy for renal diseases. Am J Kidney Dis 1996 Oct; 28(4): 475-92.
Hanss B, Stein CA, Klotman PE. Cellular Uptake and Biodistribution of Oligodeoxynucleotides. In: Stein CA, Krieg AM, editors. Applied antisense oligonucleotide technology. New York, Wiley-Liss, Inc.; 1998. pp111-127.
Langer JC, Klotman ME, Hanss B, Tulchin N, Bruggeman LA, Klotman PE, Lipkowitz MS. Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery. Exp Nephrol 1998 May-Jun; 6(3): 189-94.
Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE. Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA 1998 Feb 17; 95(4): 1921-6.
Lipkowitz M S, Hanss BG, Tulchin N, Wilson PD, Langer JC, Ross MD, Kurtzman GJ, Klotman PE, Klotman ME. Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors. J Am Soc Nephrol 1999 Sep; 10(9): 1908-15.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Hanss did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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