Bernhard V Sauter, MD
- ADJUNCT ASSISTANT PROFESSOR | Medicine, Gastroenterology
My laboratory covers different aspects of basic research in angiogenesis and vascular biology, employing viral gene delivery for therapeutic purposes (anti-angiogenic gene therapy for cancer), but also using gene transfer as a tool to overexpress genes related to the biology of endothelial cells, vascular smooth muscle cells and monocytes/macrophages. Different mouse models serve to study the ensuing effects of virus-mediated gene modulation in vivo in response to arterial injury and in models of hyperlipidemia-induced atherosclerosis. Furthermore, we have also embarked in studies focusing on the contribution of bone marrow-derived circulating endothelial progenitor cells and on the differentiation potential of embryonic stem cells in these models. \r\n\r\n
Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, Dorko K, Sauter B, Strom SC. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-1426.
Min AD, Saxena R, Thung SN, Attilasoy EO, Wolf DC, Sauter B, Schwartz ME, Bodenheimer Jr HC. Outcome of hepatitis C patients with and without hepatocellular carcinoma undergoing liver transplant. Am J Gastroenterol 1998; 93: 2148-2153.
Ermekova V, Qiao J, Sauter B, Mandeli JP, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model. J Natl Cancer Inst 2000; 92(11): 931-36.
Ilan Y, Weksler-Zangen S, Ben-Horin S, Diment J, Sauter B, Rabbani E, Engelhardt D, Roy-Chowdhury N, Roy-Chowdhury J, Goldin E. Treatment of experimental colitis by oral tolerance induction: A central role for suppressor lymphocytes. Am J Gastroenterol 2000; 95: 966-973.
Sauter B, Parashar B, Chowdhury NR, Kadakol A, Ilan Y, Singh H, Milano J, Strayer D, Chowdhury JR. Gene transfer to the liver in vivo using replication-deficient recombinant SV40 vectors results in long-term amelioration of jaundice in Gunn rats. Gastroenterology 2000;: 1348-1357.
Sauter BV, Martinet O, Zhang WJ, Mandeli J, Woo SL. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc Natl Acad Sci 2000 Apr; 97(9): 4802-7.
Savontaus MJ, Sauter B, Huang TG, Woo SL C. Transcriptional Targeting of Conditionally Replicating Adenovirus to Dividing Endothelial Cells. Gene Therapy 2002; 9(14): 972-979.
Qiao J, Doubrovin M, Sauter B, Huang Y, Guo ZS, Balatoni J, Akhurst T, Blasberg RG, Tjuvajev J, Chen SH, Woo SL C. Tumor-specific transcriptional targeting of suicide gene therapy. Gene Therapy 2002; 9(3): 168-175.
Huang TG, Savontaus MJ, Shinozaki K, Sauter B, Woo SL C. Telomerase dependent oncolytic adenovirus for cancer treatment. Gene Therapy 2003;.
Sauter B, Hutter R, Reis E, Roque M, Vorchheimer D, Carrick F, Fallon JT, Fuster V, Badimon JJ. Decreased reendothelialization and increased neointima formation with endostatin overexpression in a mouse model of arterial injur. Circulation 2003;.