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Bjoern Ludwar

  • ASSISTANT PROFESSOR Neuroscience
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Education

  • M.Sc., University of Erlangen-Nuremberg

  • Ph.D., University of Cologne

Research

As a biologist specializing in neurophysiology, I am interested in how a nervous system produces behavior. Specifically, what information do sensory organs gather, how is this information transmitted to the central nervous system, how do central neural circuits integrate and process signals, and how are muscles controlled?

My current projects focus on how sensory cells regulate information. Signals from the environment are not just unconditionally passed on to the central nervous system. A variety of mechanisms selects appropriate information and blocks out unimportant information to reduce the brain's workload. I study these mechanisms in invertebrate model systems using classic electrophysiology, the direct recording of the neuron's electrical activity, and optical techniques that allow visualizing specific aspects of nerve cell activity. In particular calcium imaging has proven extremely useful in uncovering the mechanisms of sensory signal regulation.

Publications

Ludwar BC, Evans CG, Cropper EC. Monitoring changes in the intracellular calcium concentration and synaptic efficacy in the mollusc. J. Vis. Exp. 2012; 65(e3907).

Jing J, Sasaki K, Perkins MH, Siniscalchi MJ, Ludwar BC, Cropper EC, Weiss KR. Coordination of distinct motor structures through remote axonal coupling of projection interneurons. J. Neurosci. 2011 Oct; 31(43).

Evans CG, Ludwar BC, Askanas J, Cropper EC. Effect of holding potential on the dynamics of homosynaptic facilitation. J. Neurosci. 2011 Jul; 31(30).

Evans CG, Ludwar BC, Kang T, Cropper EC. Effect of presynaptic membrane potential on electrical vs. chemical synaptic transmission. J. Neurophys. 2011 Aug; 106(2).

Jing J, Sweedler JV, Cropper EC, Alexeeva V, Park J, Romanova EV, Xie F, Dembrow NC, Ludwar BC, Weiss KR, Vilim FS. Feedforward Compensation Mediated by the Central and Peripheral Actions of a Single Neuropeptide Discovered Using Representational Difference Analysis. J. Neurosci. 2010 Dec; 30.

Friedman AK, Zhurov Y, Ludwar BC, Weiss KR. Motor outputs in a multi-tasking network: Relative contributions of inputs and experience-dependent network states.. J. Neurophys. 2009; 102(6): 3711-3727.

Ludwar BC, Evans CG, Jing J, Cropper EC. Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission. . J. Neurophys. 2009; 102(3): 1976-1983.

DiCaprio RA, Billimoria CP, Ludwar BC. Information rate and spike-timing precision of proprioceptive afferents.. J. Neurophys. 2007 Jul; 98(3): 1706-17.

Akay T, Ludwar B, Göritz M, Schmitz J, Büschges A. Segment Specificity of Load Signal Processing Depends on Walking Direction in the Stick Insect Leg Muscle Control System.. J. Neurosci. 2007; 27: 3285-3294.

Evans CG, Ludwar BC, Cropper EC. A mechanoafferent neuron with an inexcitable somatic region: Consequences for the regulation of spike propagation and afferent transmission.. J. Neurophys. 2007; 97: 3126-3130.

Ludwar BC, Westmark S, Büschges A, Schmidt J. Modulation of Membrane Potential in Mesothoracic Moto- and Interneurons During Stick Insect Front-Leg Walking.. J. Neurophys. 2005; 94: 2772-2784.

Brandt LE, Ludwar BC, Greenfield MD. Co-Occurrence of Preference Functions and Acceptance Thresholds in Female Choice: Mate Discrimination in the Lesser Wax Moth.. Ethology 2005; 111: 609-625.

Ludwar BC, Göritz ML, Schmidt J. Intersegmental coordination of walking movements in stick insects.. J. Neurophys. 2005; 93(3): 1255-1265.

Büschges A, Ludwar BC, Bucher D, Schmidt J, DiCaprio RA. Synaptic drive contributing to rhythmic activation of motoneurons in the deafferented stick insect walking system.. Eur. J. Neurosci. 2004; 19(7): 1856-1862.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Ludwar did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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