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Brian Radbill

  • ASSOCIATE PROFESSOR Medicine, Nephrology
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Specialty

Certifications

  • Nephrology

  • American Board of Internal Medicine

Education

  • MD, Hahnemann University

  • B.A., University of Michigan
    English

  • M.D., Hahnemann University School of Medicine

  • Mount Sinai School of Medicine
    Internal Medicine

  • Mount Sinai School of Medicine
    Nephrology

  • Internship, Internal Medicine
    Mount Sinai Hospital

  • Residency, Nephrology
    Mount Sinai Hospital

  • Fellowship, Nephrology
    Mount Sinai Hospital

Biography

    In the News

    Dr. Radbill discusses chronic kidney disease in The Daily News feature The Daily Check Up.
    View the PDF.

Research

The role of matrixmetalloproteinases (MMPs) in renal interstitial fibrosis

Renal interstitial fibrosis (RIF) is the end result of chronic kidney disease (CKD) and is predictive of long-term renal survival and its inhibition might delay progression towards end-stage renal disease (ESRD). Since type IV collagen-rich extracellular matrix is replaced by type-1 collagen after injury, the hypothesis is being tested that matrix metalloproteinase-2 (MMP-2), a type IV collagenase, may play a causative role in renal fibrosis. Mechanistic studies are underway using an MMP-2 -/- mouse to determine whether MMP-2 promotes renal tubular epithelial-mesenchymal transition (EMT), myofibroblast proliferation and fibrogenesis with and without unilateral ureteral obstruction (UUO), a murine model of RIF.

In addition, the role of MMP-2 in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) is under study comparing MMP-2 and fibrognesis marker gene and protein expression by human ADPKD epithelia versus normal renal tubular cell lines in vitro.

Frequent Hemodialysis Network (FHN): Short Daily Dialysis Study

Previously published data suggests that short daily hemodialysis (2-2.5 hours a day, 6 days a week) may be superior to conventional hemodialysis (3-4 hours a day, 3 days a week) in terms of solute clearance and fluid management. Daily hemodialysis could result in improved dialysis adequacy, improved blood pressure control, decreased cardiac disease (specifically, left ventricular hypertrophy), and decreased mortality. We are working with RRI (Renal Research Institute) as part of a multi-center NIH funded clinical trial studying the potential benefits of short daily hemodialysis versus conventional hemodialysis.

Publications

Vassalotti JA, Radbill BD, Klotman ME, Klotman PE. Hepatitis and HIV-related Renal Diseases. In: Brady HR, Wilcox CS, editors. Therapy in Nephrology and Hypertension. Companion to Brenner and Rector's The Kidney. 2nd Philadelphia, PA, W.B. Saunders Co; 2003. pp261-70.

Bansal MB, Kovalovich K, Gupta R, Li W, Agarwal A, Radbill B, Alvarez CE, Safadi R, Fiel MI, Friedbam SL, Taub RA. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol 2005 Apr; 42(4): 548-56.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Radbill did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Insurance Plans
  • Aetna U.S. Healthcare
  • Devon Health Services
  • Empire Blue Cross/Blue Shield
  • Medicare
  • Oxford Health Plans
  • Prem Preferred Care/Beechstreet
  • Private Healthcare Systems (PHCS)
  • Prudential Healthcare: a member company of Aetna
  • United Healthcare