Photo of Chenleng Cai

Chenleng Cai

  • ASSOCIATE PROFESSOR Developmental and Regenerative Biology
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Biography

Awards

  • 2009 - 2014
    Independent Investigator Award
    NIH/NHLBI

  • 2008 - 2010
    Basil O'Connor Starter Scholar
    March of Dimes

  • 2008 - 2011
    Grant-in-Aid
    American Heart Association

  • 2004 -
    Schuman Award
    University of California, San Diego

  • 2004 - 2008
    National Scientist Development Grant
    American Heart Association

  • 2001 - 2003
    Postdoctoral Fellowship
    American Heart Association

Research

Summary of Research Studies:

 
Cardiogenesis, the induction and subsequent development of the heart, is a critical event during embryogenesis. Mutations in genes expressed in the early heart cause defective cardiac development, and are responsible for embryonic lethality and congenital heart disease, occurring in ~1% of live births and 10% of stillbirths in humans. The Cai laboratory uses mouse as a model system to study the molecular pathways controlling heart development and disease. Uncovering signaling cascades underlying early heart development also has great implications for the research of cardiac regenerative biology. Dr. Cai's previous research has showed that Isl1 (Islet1), a Lim-homeodomain transcription factor, labels a cardiac progenitor population that gives rise to the majority of cardiac segments (right ventricle, outflow tract and atria). Loss of Isl1 results in a malformed heart that lacks these cardiac segments during early heart development. In addition to the study of Isl1, Dr. Cai also discovered that T-box transcription factor Tbx20 plays critical roles in regulating cardiac cell proliferation and specification. More recently, Dr. Cai identified another cardiac progenitor population, Tbx18-expressing proepicardial and epicardial cells that can gives rise to both myocytes and non-myocytes cardiac lineages during early heart development. The Cai laboratory is currently performing research to decipher the transcriptional networks of Isl1 and Tbx20 in heart development. They are also interested in exploring the therapeutic potential of Isl1 and Tbx18 progenitor cells in cardiac repair and regeneration.

For more information, please visit the Cai Laboratory website.

Publications

Lu Zhang, Aya Nomura-Kitabayashi, Nishat Sultana, Weibin Cai, Xiaoqiang Cai, Anne M. Moon, Chen-Leng Cai, Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Developmental biology, in press;.

Wang J, Li Z, He Y, Pan F, Chen S, Rhodes S, Nguyen L, Yuan J, Jiang L, Yang X, Weeks O, Liu Z, Zhou J, Ni H, Cai CL, Xu M, Yang FC. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood 2014 Jan; 123(4).

Cai X, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development (Cambridge, England) 2013 Aug; 140(15).

Grisanti L, Clavel C, Cai X, Rezza A, Tsai SY, Sennett R, Mumau M, *Cai CL, *Rendl M. Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. The Journal of investigative dermatology 2013 Feb; 133(2): *co-corresponding authors.

Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma'ayan A, Rendl M. Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Developmental cell 2012 Nov; 23(5).

Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. The Journal of clinical investigation 2011 Dec; 121(12).

Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL. Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2. Developmental biology 2011 Dec; 360(2).

Zhang W, Chen H, Wang Y, Yong W, Zhu W, Liu Y, Wagner GR, Payne RM, Field LJ, Xin H, Cai CL, Shou W. Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function. The Journal of biological chemistry 2011 Oct; 286(42).

Li Z, Cai X, Cai CL, Wang J, Zhang W, Petersen BE, Yang FC, Xu M. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 2011 Oct; 118(17).

Nie X, Sun J, Gordon RE, Cai CL, Xu PX. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development (Cambridge, England) 2010 Mar; 137(5).

Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes 2009 Sep; 58(9).

Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature 2008 Jul; 454(7200).

Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America 2007 May; 104(22).

Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans SM. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Developmental biology 2007 Apr; 304(1).

Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans SM, Lee SK, Pfaff SL. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development (Cambridge, England) 2006 Dec; 133(24).

Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Developmental biology 2006 Aug; 296(2).

Lin L, Bu L, Cai CL, Zhang X, Evans S. Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Developmental biology 2006 Jul; 295(2).

Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (Cambridge, England) 2006 Jun; 133(12).

Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development (Cambridge, England) 2006 Apr; 133(8).

Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development (Cambridge, England) 2005 May; 132(10).

Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005 Feb; 433(7026).

Huang C, Sheikh F, Hollander M, Cai CL, Becker D, Chu PH, Evans S, Chen J. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development (Cambridge, England) 2003 Dec; 130(24).

Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Developmental cell 2003 Dec; 5(6).

Sparrow DB, Cai CL, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ. Regulation of the tinman homologues in Xenopus embryos. Developmental biology 2000 Nov; 227(1).

Shi Y, Katsev S, Cai CL, Evans S. BMP signaling is required for heart formation in vertebrates. Developmental biology 2000 Aug; 224(2).

Chu PH, Ruiz-Lozano P, Zhou Q, Cai CL, Chen J. Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. Mechanisms of development 2000 Jul; 95(1-2).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Cai did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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