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Chiara Giannarelli, MD, PhD
img_Chiara Giannarelli
ADJUNCT ASSOCIATE PROFESSOR | Medicine, Cardiology
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Research Topics
Atherosclerosis, Cardiovascular, Gene Expressions, Imaging, Immunology, Inflammation, Macrophage, Systems Biology, T Cells
Immunity and Cardiovascular Disease
We study the contribution of inflammatory cells infiltrating the atherosclerotic arterial wall to the progression of the disease:  identification of the cellular and molecular immune interactions that occur in the atherosclerotic plaque


Angiogenesis in Atherosclerosis
We investigate the contribution of circulating monocyte subsets as a source of a new isoform of tissue factor with angiogenic activity to the growth of intimal neovessel in atherosclerosis as a potential mechanism of lesion instability culminating in the onset of ischemic cardiovascular events (i.e. stroke and myocardial infarction).

MD, University of Pisa

PhD, University of Pisa (Dept. of Pharmacology)

Post-Doctoral Fellow, Mount Sinai School of Medicine

Residency, University of Pisa

2017

The Role of P2X7 in HIV-Infected Individuals with Atherosclerotic Cardiovascular, Multidisciplinary Research Development Initiative

Department of Medicine, Icahn School of Medicine at Mount Sinai

2016

Dissecting the cellular and molecular immune interactions in human atherosclerosis

NIH-NHLBI

2016

NETWORK-DRIVEN DRUG REPURPOSING APPROACHES TO TREAT CORONARY ARTERY DISEASE

NIH-NCATS

2015

Multidisciplinary Research Development Initiative

Department of Medicine, Icahn School of Medicine at Mount Sinai

2013

Career Development Award

NIH-NHLBI

94
Publications

Selected Publications

BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues. Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goate. Nature Communications

The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis. Yannick Cyr, Fazli K. Bozal, José Gabriel Barcia Durán, Alexandra A.C. Newman, Letizia Amadori, Panagiotis Smyrnis, Morgane Gourvest, Dayasagar Das, Michael Gildea, Ravneet Kaur, Tracy Zhang, Kristin M. Wang, Richard Von Itter, P. Martin Schlegel, Samantha D. Dupuis, Bernard F. Sanchez, Ann Marie Schmidt, Edward A. Fisher, Coen van Solingen, Chiara Giannarelli, Kathryn J. Moore. Proceedings of the National Academy of Sciences of the United States of America

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels. Natalia Eberhardt, Maria Gabriela Noval, Ravneet Kaur, Letizia Amadori, Michael Gildea, Swathy Sajja, Dayasagar Das, Burak Cilhoroz, O’ Jay Stewart, Dawn M. Fernandez, Roza Shamailova, Andrea Vasquez Guillen, Sonia Jangra, Michael Schotsaert, Jonathan D. Newman, Peter Faries, Thomas Maldonado, Caron Rockman, Amy Rapkiewicz, Kenneth A. Stapleford, Navneet Narula, Kathryn J. Moore, Chiara Giannarelli. Nature Cardiovascular Research

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