Research Topics
Biography
Research
High-Throughput Screening
Dan Felsenfeld is the director of the Integrated Screening Core (ISC) at the Mount Sinai School of Medicine.
The ISC assists investigators with the design, execution and analysis of high-throughput and high-content screens of small molecule and siRNA libraries.
Additional information can be found on the ISC web site: isc.mssm.edu
Publications
Sakurai T, Gil OD, Whittard JD, Gazdoiu M, Joseph T, Wu J, Waksman A, Benson DL, Salton SR, Felsenfeld DP. Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation. Journal of neuroscience research 2008 Sep; 86(12).
whittard jd, sakurai t, cassella mr, gazdoiu m, felsenfeld dp. MAP Kinase Pathway-dependent Phosphorylation of the L1-CAM Ankyrin Binding Site Regulates Neuronal Growth. Mol Biol Cell 2006 Jun; 17(6).
felsenfeld dp. Regulation of complexes by cytoskeletal elements: integrins serve as force transducers linking mechanical stimuli and biochemical signals [review]. Sci STKE 2005 Dec 6; 2005(313).
gil od, sakurai t, bradley ae, fink my, cassella mr, kuo ja, felsenfeld dp. Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface. J Cell Biol 2003 Aug 18; 162(4).
okigaki m, davis c, falasca m, harroch s, felsenfeld dp, sheetz mp, schlessinger j. Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci USA 2003 Sep 16; 100(19).
felsenfeld dp, schwartzberg pl, venegas a, tse r, sheetz mp. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol 1999 Aug; 1(4).
sheetz mp, felsenfeld dp, galbraith cg. Cell migration: regulation of force on extracellular-matrix-integrin complexes [review]. Trends Cell Biol 1998 Feb; 8(2).
choquet d, felsenfeld dp, sheetz mj. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 1997 Jan 10; 88(1).
yauch rl, felsenfeld dp, kraeft sk, chen lb, sheetz mp, hemler me. Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med 1997 Oct 20; 186(8).
felsenfeld dp, choquet d, sheetz mj. Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. Nature 1996 Oct 3; 383(6599).
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Felsenfeld did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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