- ADJUNCT CLINICAL INSTRUCTOR Medicine
BS, Northwestern University
MA, Jewish Theological Seminary
MD, Northwestern University Medical School
Beht Israel Hospital
Mount Sinai Medical Center
Mount Sinai Medicine Center
Am Board of Internal Medicine (Int Med)
ResearchDr. Gutstein, an investigator working in the laboratory of Dr. Glenn I. Fishman,\r\n studies the role of the gap junction in cardiac development and function. Gap\r\n junctions are specialized intercellular channels that allow the passage of ions and\r\n small molecules between cells. Connexin43 (Cx43), the most abundant gap\r\n junction protein in the heart, appears to play a critical role in heart development.\r\n Cx43-deficient mice develop right ventricular outflow tract obstruction in utero and\r\n die of pulmonary oligemia shortly after birth. Mutations in Cx43 have also been\r\n linked to human congenital heart disease. In addition, abnormalities in Cx43\r\n expression have been described in human cardiomyopathies and in animal models\r\n of arrhythmia. Modes of investigation include several murine models of the loss of\r\n Cx43 using targeted and inducible "knock-out" startegies. The lessons learned from\r\n this research program will hopefully provide insight into congenital and acquired\r\n cardiac disease and possibly provide novel targets for the treatment of heart\r\n disease.
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Dr.Gutstein is not currently required to report Industry relationships.
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