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David Gutstein

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  • BS, Northwestern University

  • MA, Jewish Theological Seminary

  • MD, Northwestern University Medical School

  • Beht Israel Hospital

  • Mount Sinai Medicine Center

  • Mount Sinai Medical Center


    Clinical Interest

    Specialty: Cardiology

    Board Certification
    Am Board of Internal Medicine (Int Med)


Dr. Gutstein, an investigator working in the laboratory of Dr. Glenn I. Fishman,\r\n studies the role of the gap junction in cardiac development and function. Gap\r\n junctions are specialized intercellular channels that allow the passage of ions and\r\n small molecules between cells. Connexin43 (Cx43), the most abundant gap\r\n junction protein in the heart, appears to play a critical role in heart development.\r\n Cx43-deficient mice develop right ventricular outflow tract obstruction in utero and\r\n die of pulmonary oligemia shortly after birth. Mutations in Cx43 have also been\r\n linked to human congenital heart disease. In addition, abnormalities in Cx43\r\n expression have been described in human cardiomyopathies and in animal models\r\n of arrhythmia. Modes of investigation include several murine models of the loss of\r\n Cx43 using targeted and inducible "knock-out" startegies. The lessons learned from\r\n this research program will hopefully provide insight into congenital and acquired\r\n cardiac disease and possibly provide novel targets for the treatment of heart\r\n disease.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Gutstein is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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