Denise Cai, PhD
img_Denise Cai
ASSOCIATE PROFESSOR | Neuroscience
Multi-Disciplinary Training Area
Neuroscience [NEU]
Research
If we live long enough, will our brains one day simply “max out” and run out of room, and if not, why not? Are memories formed and stored differently in the brain as we age? How does the way in which memories are linked over time affect what we remember? What role does sleep play in linking memories across time?

These are some of the captivating—and complex— questions about learning and memory we’re exploring in our lab. We use a multi-level approach integrating molecular, cellular, circuit-level, and behavioral techniques to investigate the dynamic nature of memory. Our primary research themes include memory capacity, temporal memory-linking, and sleep and memory. We’re studying the strategies the brain uses to optimize its capacity for storage; how prior learning influences future behavior; and why emotions may alter memories while we sleep. Building and sharing novel tools and technologies to help answer these and evolving questions in neuroscience is an exciting part of our lab’s work. We’re passionate about the open-source movement and committed to building a collaborative and generous neuroscience community.
Behavior, In Vivo Imaging, Learning & Memory, Cognitive Disorders, Hippocampus, Age-related Cognitive Deficits, Anxiety-related Disorders, Optogenetics, Chemogenetics, Activity-dependent Tagging

PhD, University of California, San Diego

2023

Friedman Brain Institute Scholar Award

2022

American College of Neuropsychopharmacology Member

2021

Irma T. Hirschl/Monique Weill-Caulier Research Award

2020

Mount Sinai Distinguished Scholar Award

Icahn School of Medicine at Mount Sinai

2020

Optogenetics GRC, Vice Chair, 2020 and Chair, 2022

2019

NIMH Research Grant (R01)

NIMH

2019

NIH Director’s New Innovator Award (DP2)

2019

McKnight Memory and Cognitive Disorder Award

2019

NARSAD Young Investigator Award

2018

Brain Research Foundation Award

2018

Klingenstein-Simons Fellowship Award

2018

Friedman Brain Scholar Award

2018

Outstanding Teaching Award

Icahn School of Medicince at Mount Sinai

2018

Botanical Center Pilot Award

2017

Allen Institute Next Generation Leader

2016

One Mind Otsuka Rising Star Award

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Dr. Cai has not yet completed reporting of Industry relationships.

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