Dorothy Grice, MD
- PROFESSOR | Psychiatry
Specialties:Child and Adolescent Psychiatry, Psychiatry
Dr. Grice is Director of the OCD and Related Disorders Clinical and Research Program and Associate Director of the Tics and Tourette’s Clinical and Research Program, both within the Division of Tics, OCD and Related Disorders (DTOR) in the Department of Psychiatry at Mount Sinai School of Medicine (MSSM). She completed clinical and research training in child psychiatry at the Yale Child Study Center (NIH Research Training Program in Childhood Neurobiological Disorders). Before joining the Icahn School of Medicine at Mount Sinai in Fall 2013 she was an Associate Professor at Columbia University and the New York State Psychiatric Institute and she was director of the Tic, Tourette and Related Disorder Clinic at Columbia Presbyterian Hospital. Dr. Grice endorses a multi-disciplinary approach to investigating, understanding and treating tics, Tourette disorder and OCD. She brings scientific expertise to the clinic and clinical acumen to the research bench. Dr. Grice has an active research program that focuses on the phenomenology, genetics and biology of tic disorders, OCD and autism spectrum disorders. Dr. Grice is completing advanced study for a Masters of Science in Bioethics at Columbia University.
Financial & Billing Information
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Child & Adolescent Psychiatry
Psychiatry, American Board of Psychiatry and Neurology
MD, Medical University of South Carolina
Residency, Psychiatry, Medical University of South Carolina
Fellowship, Child Psychiatry, Yale Child Study Center
Abdulkadir M, Tischfield JA, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, de Bruijn SF, Elzerman L, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Messchendorp MD, Mir P, Morer A, Münchau A, Murphy TL, Openneer TJ, Plessen KJ, Rath JJ, Roessner V, Fründt O, Shin EY, Sival DA, Song DH, Song J, Stolte AM, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, State MW, Heiman GA, Hoekstra PJ, Dietrich A. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of psychiatric research 2016 Jul; 82.
Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW, Ledbetter DH, Martin CL, Cook EH, Buxbaum JD, Daly MJ, Devlin B, Roeder K, State MW. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron 2015 Sep; 87(6).
Browne HA, Hansen SN, Buxbaum JD, Gair SL, Nissen JB, Nikolajsen KH, Schendel DE, Reichenberg A, Parner ET, Grice DE. Familial Clustering of Tic Disorders and Obsessive-Compulsive Disorder. JAMA psychiatry 2015 Feb;.
Chaste P, Klei L, Sanders SJ, Hus V, Murtha MT, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Mane SM, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, Lese Martin C, Beaudet AL, Lord C, State MW, Cook EH, Devlin B. A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?. Biological psychiatry 2014 Sep;.
Goodman WK, Grice DE, Lapidus KA, Coffey BJ. Obsessive-Compulsive Disorder. The Psychiatric clinics of North America 2014 Sep; 37(3).
Browne HA, Gair SL, Scharf JM, Grice DE. Genetics of Obsessive-Compulsive Disorder and Related Disorders. The Psychiatric clinics of North America 2014 Sep; 37(3).
Chaste P, Sanders SJ, Mohan KN, Klei L, Song Y, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, State MW, Martin CL, Devlin B, Beaudet AL, Cook EH, Kim SJ. Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2. Autism research : official journal of the International Society for Autism Research 2014 Jun; 7(3).
Atladottir HO, Gyllenberg D, Langridge A, Sandin S, Hansen SN, Leonard H, Gissler M, Reichenberg A, Schendel DE, Bourke J, Hultman CM, Grice DE, Buxbaum JD, Parner ET. The increasing prevalence of reported diagnoses of childhood psychiatric disorders: a descriptive multinational comparison. European child & adolescent psychiatry 2014 May;.
Ozomaro U, Cai G, Kajiwara Y, Yoon S, Makarov V, Delorme R, Betancur C, Ruhrmann S, Falkai P, Grabe HJ, Maier W, Wagner M, Lennertz L, Moessner R, Murphy DL, Buxbaum JD, Züchner S, Grice DE. Characterization of SLITRK1 Variation in Obsessive-Compulsive Disorder. PloS one 2013; 8(8).
C. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 2013 Aug; 45(9): 984-994.
Chaste P, Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Lese Martin C, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, State MW, Devlin B, Cook EH, Kim SJ. Adjusting Head Circumference for Covariates in Autism: Clinical Correlates of a Highly Heritable Continuous Trait. Biological psychiatry 2013 Jun;.
Gai X, Xie HM, Perin JC, Takahashi N, Murphy K, Wenocur AS, D'arcy M, O'Hara RJ, Goldmuntz E, Grice DE, Shaikh TH, Hakonarson H, Buxbaum JD, Elia J, White PS. Rare structural variation of synapse and neurotransmission genes in autism. Molecular psychiatry 2012 Apr; 17(4).
Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin CL, Martin DM, Morrow EM, Walsh CA, Melhem NM, Chaste P, Sutcliffe JS, State MW, Cook EH, Roeder K, Devlin B. Common genetic variants, acting additively, are a major source of risk for autism. Molecular autism 2012; 3(1).
Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011 Jun; 70(5).
Kajiwara Y, Buxbaum JD, Grice DE. SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. Biological psychiatry 2009 Nov; 66(10).
Doyle GA, Sheng XR, Lin S, Press DM, Grice DE, Buono RJ, Ferraro TN, Berrettini WH. Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene 2007; 388(1-2): 135-147.
Doyle GA, Sheng XR, Lin S, Grice DM, Buono RJ, Ferraro TN, Berrettini WH. Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene 2007; 395(1-2): 98-107.
Grice DE, Reenila I, Mannisto PT, Brooks AI, Smith GG, Golden GT, Buxbaum JD, Berrettini WH. Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. BMC Genomics 2007; 8(76).