Photo of Edythe London

Edythe London

  • ADJUNCT PROFESSOR Neuroscience
  • ADJUNCT PROFESSOR Psychiatry
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Education

  • Post-doc fellow, John Hopkins School of Medicine
    Neuropsychopharmacology, Dept. Pharmacology & Experimental Therapeutics

  • MS, Towson University
    Biological Sciences

  • PhD, University of Maryland
    Pharmacology, supporting program in Neurobiology

  • BS, George Washington University
    Zoology (minor in Chemistry)

Biography

    Dr. Edythe London is an Adjunct Professor of the Departments of Neuroscience and Psychiatry at Icahn School of Medicine in NY. She also holds the Thomas P. and Katherine K. Pike Chair of Addiction Studies, and is a Professor in the Departments of Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology at UCLA. Dr. London is an internationally recognized expert in the study of drug addiction. Dr. London received a doctoral degree in pharmacology and toxicology at the University of Maryland and postdoctoral training in neuropsychopharmacology at the Johns Hopkins School of Medicine. Before joining the UCLA faculty in 2001, she worked at the National Institutes of Health for two decades, where she directed the Neuropharmacology Research Laboratory and the Neuroimaging Research Center of the National Institute on Drug Abuse. Dr. London pioneered the application of brain imaging to the study of substance abuse. She has authored 327 original research articles and 71 chapters and reviews, edited three books, and has delivered hundreds of invited lectures within the United States and internationally. Dr. London’s work has been recognized by numerous awards, including the 2008 Marian Fischman Award from the College on Problems of Drug Dependence and the 2011 Scientific Freedom and Responsibility Award from the American Association for the Advancement of Science. For more information, please visit: http://www.semel.ucla.edu/cab http://www.semel.ucla.edu/cab/training-grant-translational-neuroscience-drug-abuse

Research

Dr. Edythe London's research uses a translational approach to develop a better understanding of addictive disorders and further the rational design of therapeutics. Her laboratory was the first to show a relationship between drug craving and activity in brain regions that underlie episodic memory and link memory with emotion. Her research also has contributed to the development of new approaches and probes for noninvasive brain imaging. Dr. London’s laboratory now focuses on stimulant and nicotine addiction.

Publications

Morales AM, Ghahremani D, Kohno M, Hellemann GS, London ED. Cigarette exposure, dependence, and craving are related to insula thickness in young adult smokers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014 Jul; 39(8).

Ivanov I, Liu X, Clerkin S, Schulz K, Fan J, Friston K, London ED, Schwartz J, Newcorn JH. Methylphenidate and brain activity in a reward/conflict paradigm: role of the insula in task performance. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2014 Jun; 24(6).

Helfinstein SM, Schonberg T, Congdon E, Karlsgodt KH, Mumford JA, Sabb FW, Cannon TD, London ED, Bilder RM, Poldrack RA. Predicting risky choices from brain activity patterns. Proceedings of the National Academy of Sciences of the United States of America 2014 Feb; 111(7).

Kohno M, Morales AM, Ghahremani DG, Hellemann G, London ED. Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence. JAMA psychiatry 2014 Jul; 71(7).

O'Neill J, Tobias MC, Hudkins M, Oh EY, Hellemann GS, Nurmi EL, London ED. Thalamic glutamate decreases with cigarette smoking. Psychopharmacology 2014 Jul; 231(13).

Courtney KE, Ghahremani DG, London ED, Ray LA. The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol. Drug and alcohol dependence 2014 Aug; 141.

Berman SM, Paz-Filho G, Wong ML, Kohno M, Licinio J, London ED. Effects of leptin deficiency and replacement on cerebellar response to food-related cues. Cerebellum (London, England) 2013 Feb; 12(1).

Ghahremani DG, Oh EY, Dean AC, Mouzakis K, Wilson KD, London ED. Effects of the Youth Empowerment Seminar on impulsive behavior in adolescents. The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2013 Jul; 53(1).

Galván A, Schonberg T, Mumford J, Kohno M, Poldrack RA, London ED. Greater risk sensitivity of dorsolateral prefrontal cortex in young smokers than in nonsmokers. Psychopharmacology 2013 Sep; 229(2).

Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013 Oct; 229(3).

Kohno M, Ghahremani DG, Morales AM, Robertson CL, Ishibashi K, Morgan AT, Mandelkern MA, London ED. Risk-Taking Behavior: Dopamine D2/D3 Receptors, Feedback, and Frontolimbic Activity. Cerebral cortex (New York, N.Y. : 1991) 2013 Aug;.

Reise SP, Moore TM, Sabb FW, Brown AK, London ED. The Barratt Impulsiveness Scale-11: reassessment of its structure in a community sample. Psychological assessment 2013 Jun; 25(2).

Ishibashi K, Robertson CL, Mandelkern MA, Morgan AT, London ED. The simplified reference tissue model with 18F-fallypride positron emission tomography: choice of reference region. Molecular imaging; 12(8).

Hudkins M, O'Neill J, Tobias MC, Bartzokis G, London ED. Cigarette smoking and white matter microstructure. Psychopharmacology 2012 May; 221(2).

Ishibashi K, Berman SM, Paz-Filho G, Lee B, Robertson C, Mandelkern MA, Wong ML, Licinio J, London ED. Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement. Molecular psychiatry 2012 Apr; 17(4).

Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Apr; 32(17).

Dean AC, Hellemann G, Sugar CA, London ED. Educational attainment is not a good proxy for cognitive function in methamphetamine dependence. Drug and alcohol dependence 2012 Jun; 123(1-3).

Payer DE, Nurmi EL, Wilson SA, McCracken JT, London ED. Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry. Translational psychiatry 2012; 2.

Morales AM, Lee B, Hellemann G, O'Neill J, London ED. Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamine. Drug and alcohol dependence 2012 Oct; 125(3).

Zorick T, Lee B, Mandelkern MA, Fong T, Robertson C, Ghahremani DG, Brown AK, Sumerel B, London ED. Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse. Molecular psychiatry 2012 Jun; 17(6).

Payer DE, Baicy K, Lieberman MD, London ED. Overlapping neural substrates between intentional and incidental down-regulation of negative emotions. Emotion (Washington, D.C.) 2012 Apr; 12(2).

Brown AK, Mandelkern MA, Farahi J, Robertson C, Ghahremani DG, Sumerel B, Moallem N, London ED. Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012 Aug; 15(7).

Ghahremani DG, Lee B, Robertson CL, Tabibnia G, Morgan AT, De Shetler N, Brown AK, Monterosso JR, Aron AR, Mandelkern MA, Poldrack RA, London ED. Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May; 32(21).

Dean AC, Sevak RJ, Monterosso JR, Hellemann G, Sugar CA, London ED. Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans. Journal of studies on alcohol and drugs 2011 Nov; 72(6).

Tabibnia G, Monterosso JR, Baicy K, Aron AR, Poldrack RA, Chakrapani S, Lee B, London ED. Different forms of self-control share a neurocognitive substrate. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar; 31(13).

Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May; 31(20).

Ghahremani DG, Tabibnia G, Monterosso J, Hellemann G, Poldrack RA, London ED. Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011 Apr; 36(5).

Zorick T, Mandelkern MA, Lee B, Wong ML, Miotto K, Shabazian J, London ED. Elevated plasma prolactin in abstinent methamphetamine-dependent subjects. The American journal of drug and alcohol abuse 2011 Jan; 37(1).

Dean AC, Sugar CA, Hellemann G, London ED. Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test. Psychopharmacology 2011 Jun; 215(4).

Payer DE, Lieberman MD, London ED. Neural correlates of affect processing and aggression in methamphetamine dependence. Archives of general psychiatry 2011 Mar; 68(3).

Galván A, Poldrack RA, Baker CM, McGlennen KM, London ED. Neural correlates of response inhibition and cigarette smoking in late adolescence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011 Apr; 36(5).

Nestor LJ, Ghahremani DG, Monterosso J, London ED. Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry research 2011 Dec; 194(3).

London ED, Berman SM, Chakrapani S, Delibasi T, Monterosso J, Erol HK, Paz-Filho G, Wong ML, Licinio J. Short-term plasticity of gray matter associated with leptin deficiency and replacement. The Journal of clinical endocrinology and metabolism 2011 Aug; 96(8).

Simon SL, Dean AC, Cordova X, Monterosso JR, London ED. Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence. Journal of studies on alcohol and drugs 2010 May; 71(3).

Azizian A, Nestor LJ, Payer D, Monterosso JR, Brody AL, London ED. Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Feb; 35(3).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.London is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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