- PROFESSOR Neuroscience
- PROFESSOR Structural and Chemical Biology
- PROFESSOR Ophthalmology
The Rockefeller University
Ph.D., Syracuse University
ResearchSpecific Clinical/Research Interests: Neurophysiology; visual neuroscience
Current Students: Chris Kananau
Research Personnel: Youping Xiao, Ph.D.; Alex Casti, Ph.D., Yunguo Yu, MD- Ph.D.
Information Processing in the Nervous (Visual) System
We explore information processing in the nervous system, and use the visual system as a convenient model. We employ systems analysis, borrowed from communication engineering, as the conceptual and methodological framework. We have developed sophisticated techniques for stimulation of the visual system, and for the analysis of neuronal responses to these stimuli. We use single unit recordings and optical imaging of neuronal activity. We also record simultaneously the input and output of neurons in the visual thalamic nucleus, the lateral geniculate nucleus (LGN), in order to learn how information transmission from the retina to the visual cortex through the LGN is controlled. Applied mathematics and computers are used extensively for stimulation, analysis and modeling of the systems under study.
Currently we are investigating the properties of visual neurons in the retina, LGN and visual cortex of monkeys and cats, with an emphasis on the temporal, spatial and chromatic selectivities of these cells, and on the nature, source and function of the variability (noise) of neuronal responses. Since perception and behavior involve the coordinated activity of many interacting neurons, we also image the spatio-temporal distribution of activity in neuronal ensembles in the visual cortex. In addition, the experimental approaches are augmented by computational modeling of LGN neurons and cortical circuits.
Optical imaging of ocular dominance columns in monkey visual cortex. Dark bands respond to left eye stimulation; light bands respond to right eye stimulation
(From E. O'Brien's thesis)
Left: A map of the primate cortical region that process chromatic information (red/green in this case).
Right: Autocorrelation of the image on the left, showing the spatial scale of the chromatic system
(From D. Orbach's thesis).
Optical signals recorded from the cat visual cortex closely reflect the firing rate of single cortical neurons
(From E. O'Brien's thesis).
For part 2 of the nice little movie, click here.
For the next portion of the nice little movie, click here.
For the exciting conclusion of the nice little movie, click here.
Visit Dr. Ehud Kaplan's Visual and Computational Neuroscience for more information.
Casti A, Hayot F, Xiao Y, Kaplan E. A simple model of retinal-LGN transmission. J. Comp. Neurosc 2007;.
Xiao Y, Casti A, Xiao J, Kaplan E. Hue maps in primate striate cortex. NeuroImage 2007; 35(2): 771-786.
Ozaki T, Kaplan E. Brainstem input modulates globally the transmission through the lateral geniculate nucleus. Inter. Journal of Neurosci 2006; 116: 247-264.
Kaplan E. The M, P and K pathways in the Primate Visual System. In: Chalupa L, Werner J, editors. The Visual Neuroscience Encyclopedia. 2003. pp481-494.
Sornborger AT, Sailstad C, Kaplan E, Sirovich L. Spatio-Temporal Analysis of Optical Imaging Data. Neuroimage 2003; 18: 610-621.
Sirovich L, Kaplan E. Analysis Methods for Optical Imaging. In: Frostig RD, editor. In Vivo Optical Imaging of Brain Function . CRC Press LLC; 2002. pp43-76.
Casti AR, Omurtag A, Sornborger A, Kaplan E, Knight B, Victor J, Sirovich L. A Population Study of Integrate-and-Fire-or-Burst Neurons. Neural Computation 2002; 14: 957-986.
Benardete EA, Kaplan E. Dynamics of Primate P Retinal Ganglion Cells: Responses to Chromatic and Achromatic Stimuli. J Physiol 1999; 519: 775-790.
Everson RM, Prashanth AK, Knight BW, Sirovich L, Kaplan E. Representation of Spatial Frequency and Orientation in the Visual Cortex. Proc Natl Acad Sci USA 1998; 95: 8334-8338.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Kaplan did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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