- ASSISTANT PROFESSOR Medicine, Clinical Immunology
Ph.D., University of Nantes
M.S., Lebanese University
Postdoctoral Fellow, McGill University
M.S., University of Burgundy
ResearchOur laboratory studies signaling pathways regulating innate immunity and cell death. The research focus is to elucidate the molecular mechanisms and roles of cytosolic pattern recognition receptors of the Nod-like receptor (NLR) family in host defense, chronic inflammation and cancer.
Several established approaches, ranging from genetically modified mouse models to biochemistry and cellular immunology methods, are used in our laboratory to gain insight into the mechanisms that govern host-pathogen interactions, tumor biology and inflammatory-mediated immune disorders.
We are particularly investigating the functions of various apoptosis effectors in infection, inflammatory bowel diseases and colorectal cancer.
Postdoctoral and graduate projects are regularly available.
Saxena M, Yeretssian G. NOD-Like Receptors: Master Regulators of Inflammation and Cancer. Frontiers in Immunology 2014 Jul 14;5:327. doi: 10.3389/fimmu.2014.00327.
Parlato M, Yeretssian G. NOD-like receptors in intestinal homeostasis and epithelial tissue repair. International Journal of Molecular Sciences 2014 May 30;15(6):9594-627. doi: 10.3390/ijms15069594.
Mathern DR, Laitman LE, Hovhannisyan Z, Dunkin D, Farsio S, Malik TJ, Roda G, Chitre A, Iuga AC, Yeretssian G, Berin MC, Dahan S. Mouse and human Notch-1 regulate mucosal immune responses. Mucosal Immunology 2014 Jul;7(4):995-1005. doi: 10.1038/mi.2013.118. Epub 2014 Jan 15.
Roda G., Jianyu X., Park M., Hovhannisyan Z., Couri R., Stanners C., Yeretssian G., Mayer L. Characterizing CEACAM5 interaction with CD8α and CD1d in intestinal homeostasis. Mucosal Immunology 2014 May;7(3):615-24. doi: 10.1038/mi.2013.80. Epub 2013 Oct 9.
Meunier C., Van Der Kraak L., Turbide C., Groulx N., Labouba I., Cingolani P., Blanchette M., Yeretssian G., Mes-Masson AM., Saleh M., Beauchemin N., Gros P. Positional mapping and candidate gene analysis of the mouse ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. PLOS One 2013; 8: e58733.
Muniz LR., Knosp C., Yeretssian G. Intestinal antimicrobial peptides during homeostasis, infection and disease. Frontiers in Immunology 2012; 3:310.
Yeretssian G. Effector functions of NLRs in the intestine: innate sensing, cell death, and disease. Immunologic Research 2012; 54 (1-3):25-36.
Yeretssian G., Correa RC., Doiron K., Fitzgerald P., Dillon CP., Green DR., Reed JC., Saleh M. Non- apoptotic role of BID in inflammation and innate immunity. Nature 2011, 474(7349): 96-9.
Labbe K., *Miu J., *Yeretssian G., Serghides L., Tam M., Finney CA., Erdman LK., Goulet ML., Kain KC., Stevenson MM., Saleh M. Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kB signaling. Journal of Immunology 2010, 185(9): 5495-502. *(Shared second authorship)
*Dupaul-Chicoine J., *Yeretssian G., Doiron K., Bergstrom KS., McIntire CR., LeBlanc PM., Meunier C., Turbide C., Gros P., Beauchemin N., Vallance BA., Saleh M. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 2010, 32(3):367-78. *(Shared first authorship)
Yeretssian G., Doiron K., Shao W., Leavitt BR., Hayden MR., Nicholson DW., Saleh M. Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proceedings of the National Academy of Science 2009, 106(22): 9016-20.
*McIntire CR., *Yeretssian G., Saleh M. Inflammasomes in infection and inflammation. Apoptosis 2009, 14(4): 522-35. *(Shared first authorship)
Yeretssian G., Labbe K., Saleh M. Molecular regulation of inflammation and cell death. Cytokine 2008, 43(3):380-90.
LeBlanc PM., Yeretssian G., Rutherford N., Doiron K., Nadiri A., Zhu L., Green DR., Gruenheid S., Saleh M. Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host and Microbe 2008, 13; 3(3): 146-57.
Gaudin JC., Rabesona H., Choiset Y., Yeretssian G., Chobert JM., Sakanyan V., Haertle T. Assessment of the IgE-mediated immune response to milk-specific proteins in allergic patients using microarrays. Clinical and Experimental Allergy 2008, 38(4): 686-93.
Shao W., Yeretssian G., Doiron K., Hussain SN., Saleh M. The caspase-1 digestome identifies the glycolysis pathway as a caspase-1 target during Salmonella infection and in septic shock. Journal of Biological Chemistry 2007, 282(50): 36321-9.
Yeretssian G., Lecocq M., Lebon G., Hurst H.C., Sakanyan V. Competition on nitrocellulose immobilized antibody arrays: From bacterial protein binding assay to protein profiling in breast cancer cells. Molecular and Cellular Proteomics 2005, 4(5), 605-617.
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