Hanna Y Irie, MD, PhD
- ASSISTANT PROFESSOR | Medicine, Hematology and Medical Oncology
- ASSISTANT PROFESSOR | Oncological Sciences
Research Topics:Anti-Tumor Therapy, Cancer, Cell Biology, Cell Transformation, Growth Factors and Receptors, Protein Kinases
I am a medical oncologist specializing in the care of patients with breast cancer. As a physician-scientist, I also lead a research laboratory that is focused on developing targeted therapies tailored for specific breast cancer subtypes and for individual patients. I have a particular interest in better understanding triple negative breast cancers, with the goal of integrating genetic analysis to the development of improved treatments for our patients.
I am co-PI of the Breast Tumor Biospecimen Repository, which is a bank of patient breast tumors; analysis of these tumors will provide insights into the genetic changes that determine sensitivity to specific targeted therapies for breast cancer. I am also co-PI of a study investigating the use of patient-derived xenograft models as a model for chemotherapy treatment sensitivity for patients with triple negative breast cancers; if successful, these models may be used in the future to help us better tailor treatments for individual patients. My research laboratory has identified several new candidate therapeutic targets for Her2+ and triple negative breast cancers resistant to current treatments, and we are working to translate our findings to clinical studies and trials.
I am a member of the American Society of Clinical Oncology and the American Association for Cancer Research.
MD/PHD, Harvard Medical School
BA, Harvard University
Clinical Fellow, Dana-Farber Cancer Institute
Instructor, Dana-Farber Cancer Institute/Harvard Medical School
Intern/Resident, Massachusetts General Hospital
MD, Harvard Medical School
PhD, Harvard Medical School
Research Fellow, Harvard Medical School
Residency, Internal Medicine, Massachusetts General Hospital
Fellowship, Hematology/Oncology, Dana Farber Cancer Institute
Breast Cancer Alliance Exceptional Project Grant
Breast Cancer Research Foundation Grant
AACR-Genentech BioOncology Career Development Award for Research on the Her Family in Cancer
Susan G Komen Career Catalyst Award
Dana Farber Cancer Institute SPORE in Breast Cancer Career Development Award
Terri Brodeur Breast Cancer Research Foundation Grant
AACR Scholar-in-Training Award
K08 Mentored Clinical Scientist Award
ASCO Young Investigator Award
Ravichandran KS, Pratt JC, Sawasdikosol S, Irie HY, Burakoff SJ. Coreceptors and adapter proteins in T-cell signaling [review]. Annals of the New York Academy of Sciences 1995 Sep; 766.
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. The Journal of cell biology 2005 Dec; 171(6).
McKay DB, Irie HY, Hollander G, Ferrara JL, Strom TB, Li Y, Burakoff SJ. Antigen-induced unresponsiveness results in altered T cell signaling. Journal of immunology (Baltimore, Md. : 1950) 1999 Dec; 163(12).
Irie HY, Jaklitsch MT, Shaffer K, Weinstein M, Salgia R. Unusual problems in breast cancer and a rare lung cancer case. Case 4. Primary lymphoepithelioma-like carcinoma of the lung. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003 Jun; 21(11).
Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer research 2005 Dec; 65(23).
Irie HY, Mong MS, Itano A, Crooks ME, Littman DR, Burakoff SJ, Robey E. The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development. Journal of immunology (Baltimore, Md. : 1950) 1998 Jul; 161(1).