Photo of Isabelle Germano

Isabelle Germano

  • PROFESSOR Neurosurgery
  • PROFESSOR Neurology
  • PROFESSOR Oncological Sciences
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Certifications

  • Neurological Surgery

Education

  • MD, University of Turin Medical School

  • Residency, Surgery
    Univ. of California, San Francisco

  • Residency, Neurosurgery
    Univ. of California, San Francisco

  • Residency, Neurosurgery
    Albert Einstein College of Medicine

  • Fellowship, Neurosurgery
    University of Zurich

  • Fellowship, Neurosurgery
    Montreal Neurological Institute

Biography

    Dr. Germano joined the faculty at Mount Sinai in 1993. She is Director of The Mount Sinai Comprehensive Brain Tumor Program, an advanced multidisciplinary program based on computer-assisted image-guided neurosurgery and brain mapping to accomplish minimally invasive procedures and treatment of brain tumors, and is Co-director of the Radiosurgery Program.

    You can learn more about Dr. Germano by visiting the Neurosurgery Tumors website.

    Her specialty interests include Brain Tumors, Computer-Assisted Image-Guided Neurosurgery, Epilepsy surgery and  Radiosurgery. She is Director of The Mount Sinai Medical Center Comprehensive Brain Tumor Program, an advanced multidisciplinary program based on computer-assisted image-guided neurosurgery and brain mapping to accomplish minimally invasive procedures and treatment of brain tumors. Dr. Germano is one of the pioneers of computer-assisted image-guided neurosurgery. This sophisticated technology, including the Novalis Shaped Beam Surgery, is used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease and movement disorders. Active in national neurosurgery organizations, she has served as an executive committee member for the Congress of Neurosurgery (CNS), as a Board of Directors' member for the American Association of Neurological Surgeons, as an executive committee member of the AANS/CNS Joint Section on Tumors, and as a scientific program member for the AANS, CNS, and the American Epilepsy Society. For the past five years she has directed a course, Advanced Techniques in Image-Guided Brain and Spine Surgery, for neurosurgeons from around the country.In the News

    Dr. Germano and her work diagnosing and treating brain tumors were recently profiled in The Daily News feature The Daily Check Up. View the PDF.

Awards

  • 2014 -
    Leksell Radiosurgery Award
    American Association of Neurological Surgeons

  • 2013 -
    Technology Development Award
    Icahn School of Medicine at Mount Sinai

  • 2012 - 2016
    Neurological Devices Voting Member
    Food and Drug Administration

  • 2008 - 2013
    Research grant: Brain tumors and gene transfer
    National Institute of Health

  • 2007 -
    Brain Tumor Research
    Goldhirsh Foundation

  • 2006 -
    Life Time Member
    Who is Who Strathmore's

  • 2006 -
    New York State Certificats of Recognition, Dedication and Service to the Italians Culture and Community
    New York State

  • 2005 -
    Certificate of Excellence in Youth Education
    New York City Department of Education and Mount Sinai School of Medicine

  • 2004 -
    Neurosurgery Research Award
    New York State Society

  • 2002 - 2006
    America's Top Cancer Doctors
    Castle Connolly

  • 2000 - 2006
    Top Doctors New York Metro Area
    Castle Connolly

  • 2000 - 2006
    Best Doctors Of New York
    New York Magazine

  • 1994 -
    Mary Putnam Jacobi Award
    Women's Medical Association of New York City

  • 1993 -
    W. Penfield Award
    American Epilepsy Society

Research

Translational research for malignant brain tumors
The main focus of the laboratory is to investigate new strategies for adjuvant treatment of malignant brain tumors. With the support from the National Institutes of Health, NIH, private foundations and Industry, the laboratory has been very productive in investigating new promising modalities and compound to kill brain tumor cells. Embryonic stem cells are currently used in animal models to transfer genes to brain tumors.

Image-guide computer-assisted neurosurgery
One of the pioneers in this field, Dr. Germano continues to collaborate with the industry in making neurosurgical resections more accurate and less invasive.

Related Link:
Brain Tumor and Gene Therapy Laboratory

Publications

Germano IM, Emdad L, Qadeer ZA, Binello E, Uzzaman M. Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.. Cancer Gene Ther 2010 Jun;: Epub ahead.

Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries IB, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnick CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz ST. ACR appropriateness criteria on metastatic bone disease.. J Am Coll Radiol 2010 Jun; 7(6): 400-409.

Videtic GM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology Appropriateness Criteria® topic, Multiple Brain Metastases. J Radiation Oncology Biology Physics 2009 Nov; 75(4): 961-965.

Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?. J Neurooncol 2009 Aug; 94(1): 145-148.

Germano IM, Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 2009 May; 93(1): 79-87.

Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2009 Apr; 11(2): 102-108.

Gonzales A, Sullivan G, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano IM, Mullen M, Simpson D. . Inflammatory Pseudotumor associated with HIV-JCV an immune-reconstruction syndrome. Neurology 2009 Jan; 72(3): 289-290.

Benzil D, Abosch A, Germano IM, Gilmer H, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 2008 Sept; 109(3): 378-386.

Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 2008 Sept; 7(9): 1341-1347.

Uzzaman M, Keller G, Germano I. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2008 Apr; 11(2): 102-108.

Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 2007 Apr; 106(4): 646-651.

Germano I, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 2006 July; 105(1): 88-95.

Uzzaman M, Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 2005 Sept; 19(3): E6.

Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 2005 July; 103(1): 115-123.

Benveniste R, Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 2005 June; 63(6): 542-549.

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 2005 June; 24(6): 980-991.

Mccormick PJ, Osborn IP, Germano IM, Green S, Deiner SG. Scalp nerve blockade reduces pain after headframe placement in radiosurgery: a double blind, randomized clinical trial. Middle East journal of anesthesiology 2013 Feb; 22(1).

Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surgical neurology international 2012; 3(Suppl 2).

Binello E, Qadeer ZA, Kothari HP, Emdad L, Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro. Journal of Cancer 2012; 3.

Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro-oncology 2012 Mar; 14(3).

Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem cells and development 2012 Feb; 21(3).

Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries IB, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnik CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz ST. ACR appropriateness criteria on metastatic bone disease. Journal of the American College of Radiology : JACR 2010 Jun; 7(6).

Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano I. A prospective emergency room-based study pattern and outcome of neurological and neurosurgical diseases in Haiti. World neurosurgery 2013 Oct;.

Binello E, Emdad I, Mormone E, Germano I. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. Neuro-Oncology 2013;.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Germano during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • Vital Images, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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