Isabelle M. Germano

PROFESSOR Neurosurgery
PROFESSOR Neurology
PROFESSOR Oncological Sciences

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Email

isabelle.germano@mountsinai.org

Specialty

Neurological Surgery

Certifications

Neurological Surgery

Clinical Focus

Research Topics

Training Areas

Developmental and Stem Cell Biology [DSCB]

Education

MD, University of Turin Medical School
Residency, Surgery
Univ. of California, San Francisco
Residency, Neurosurgery
Univ. of California, San Francisco
Residency, Neurosurgery
Albert Einstein College of Medicine
Fellowship, Neurosurgery
University of Zurich
Fellowship, Neurosurgery
Montreal Neurological Institute

Biography

Neurosurgery Tumors website

Advanced Techniques in Image-Guided Brain and Spine Surgery

Dr. Germano and her work diagnosing and treating brain tumors were recently profiled in The Daily News feature The Daily Check Up. View the PDF.

Awards

2008 - 2012
Research grant: Brain tumors and gene transfer
National Institute of Health
2007 -
Brain Tumor Research
Goldhirsh Foundation
2006 -
New York State Certificats of Recognition, Dedication and Service to the Italians Culture and Community
New York State
2006 -
Life Time Member
Who is Who Strathmore's
2005 -
Certificate of Excellence in Youth Education
New York City Department of Education and Mount Sinai School of Medicine
2004 -
Neurosurgery Research Award
New York State Society
2002 - 2006
America's Top Cancer Doctors
Castle Connolly
2000 - 2006
Top Doctors New York Metro Area
Castle Connolly
2000 - 2006
Best Doctors Of New York
New York Magazine
2000 - 2006
America's Top Doctors 1-5th edition
Castle Connolly
1994 -
Mary Putnam Jacobi Award
Women's Medical Association of New York City
1993 -
W. Penfield Award
American Epilepsy Society

Research

Translational research for malignant brain tumors
The main focus of the laboratory is to investigate new strategies for adjuvant treatment of malignant brain tumors. With the support from the National Institutes of Health, NIH, private foundations and Industry, the laboratory has been very productive in investigating new promising modalities and compound to kill brain tumor cells. Embryonic stem cells are currently used in animal models to transfer genes to brain tumors.

Image-guide computer-assisted neurosurgery
One of the pioneers in this field, Dr. Germano continues to collaborate with the industry in making neurosurgical resections more accurate and less invasive.

Related Link:
Brain Tumor and Gene Therapy Laboratory

Publications

Germano IM, Emdad L, Qadeer ZA, Binello E, Uzzaman M. Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.. Cancer Gene Ther 2010 Jun;: Epub ahead.

Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries IB, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnick CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz ST. ACR appropriateness criteria on metastatic bone disease.. J Am Coll Radiol 2010 Jun; 7(6): 400-409.

Videtic GM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology Appropriateness Criteria® topic, Multiple Brain Metastases. J Radiation Oncology Biology Physics 2009 Nov; 75(4): 961-965.

Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?. J Neurooncol 2009 Aug; 94(1): 145-148.

Germano IM, Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 2009 May; 93(1): 79-87.

Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2009 Apr; 11(2): 102-108.

Gonzales A, Sullivan G, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano IM, Mullen M, Simpson D. . Inflammatory Pseudotumor associated with HIV-JCV an immune-reconstruction syndrome. Neurology 2009 Jan; 72(3): 289-290.

Benzil D, Abosch A, Germano IM, Gilmer H, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 2008 Sept; 109(3): 378-386.

Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 2008 Sept; 7(9): 1341-1347.

Uzzaman M, Keller G, Germano I. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2008 Apr; 11(2): 102-108.

Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 2007 Apr; 106(4): 646-651.

Germano I, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 2006 July; 105(1): 88-95.

Uzzaman M, Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 2005 Sept; 19(3): E6.

Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 2005 July; 103(1): 115-123.

Benveniste R, Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 2005 June; 63(6): 542-549.

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 2005 June; 24(6): 980-991.

Clinical Trials

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Germano during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

Vital Images, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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