Ivone A Gomes, PhD
- ASSOCIATE PROFESSOR | Pharmacological Sciences
Dr. Gomes is a member of the Devi Laboratory within the Department of Pharmacology and Systems Therapeutics.
BSc, Bombay University
MSc, Bombay University
PhD, All India Institute of Medical Sciences
All India Institute of Medical Sciences Ph.D. Fellowship
Exploration of the functional implications of the heterodimerization between opioid receptors and other G-protein coupled receptors
My primary research interests include the investigation of G-protein coupled receptor cross-talk and mechanisms involved in G-protein coupled receptor heterodimerization/oligomerization. We have shown that two functional receptors- mu and delta opioid receptors- associate with each other (i.e. heterodimerize) to form complexes with pharmacological and signaling properties quite distinct from each individual receptor. Occupancy of the delta opioid receptor with a low non-activating dose of selective delta drugs increases the binding and signaling properties of agonists acting at the mu receptors. This work provides a model for the development of a new generation of narcotic analgesics which would have a lower tendency to induce side-effects such as addiction and tolerance. We have also shown that mu opioid receptor signaling can be modulated by heterodimerization with either alpha 2A or CB1 cannabinoid receptors. We are currently investigating the mechanisms involved as well as the physiological relevance of receptor heterodimerization.
Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, Battini L, Gusella GL, Lachmann A, Ma'ayan A, Blitzer RD, Devi LA. Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. PloS One 2012; 7(1).
Abul-Husn NS, Annangudi SP, Ma'ayan A, Ramos-Ortolaza DL, Stockton SD, Gomes I, Sweedler JV, Devi LA. Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. PloS One 2011; 6(10).
Gupta A, Devi LA, Gomes I. Potentiation of μ-opioid receptor-mediated signaling by ketamine. J Neurochem 2011 Oct; 119(2).
Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, Lee-Ramos D, Nieto N, Devi LA. AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 2011 Jun; 30(12).
Gomes I, Ijzerman AP, Ye K, Maillet EL, Devi LA. G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding. Mol Pharmacol 2011 Jun; 79(6).
Gupta A, Mulder J, Gomes I, Rozenfeld R, Bushlin I, Ong E, Lim M, Maillet E, Junek M, Cahill CM, Harkany T, Devi LA. Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal 2010 July; 3(131): rs54.
Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE. The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem 2010 Jun; 113(5): 1275-1284.
Moron JA, Gullapalli S, Taylor C, Gupta A, Gomes I, Devi LA. Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation. Neuropsychopharmacology 2010 Mar; 35(4): 955-966.
Gomes I, Grushko JS, Golebiewska U, Hoogendoorn S, Gupta A, Heinmann AS, Ferro ES, Scarlata S, Fricker LD, Devi LA. Novel endogenous peptide agonists of cannabinoid receptors. FASEB J 2009 Sep; 23(9).