James F Sumowski, PhD
- ASSOCIATE PROFESSOR | Neurology
- ASSOCIATE PROFESSOR | Psychiatry
Research Topics:Cognitive Neuroscience, Memory, Multiple Sclerosis
James F. Sumowski, Ph.D. is an Associate Professor of Neurology at Mount Sinai and neuropsychologist in the Corinne Goldsmith Dickinson Center for Multiple Sclerosis (MS). Dr. Sumowski specializes in cognitive processing and memory, and he is the foremost leader on the concept of reserve against cognitive decline among persons with MS: the notion that healthy active lifestyles provide protection against decline despite MS disease. His work has been published in high impact neurology journals (e.g., Brain, Neurology), and he has provided platform presentations at national and international meetings (e.g., AAN, ECTRIMS). Dr. Sumowski's work on cognition in MS has been principally funded by the National Institutes of Health (NIH), and he is now leading a large prospective NIH R01 project investigating modifiable risk and protective factors linked to cognitive decline in persons with MS.
BA, Seton Hall University
PhD, Columbia University
Internship, Neuropsychology, Long Island Jewish Medical Center
Fellowship, Neuropsychology, New Jersey Medical School - Rutgers University
Reserve against Cognitive Decline due to Multiple Sclerosis
Cognitive decline is common among persons with neurologic diseases, including multiple sclerosis (MS); however, some persons are better able to withstand neurologic disease without difficulties in thinking or memory. Dr. Sumowski's research seeks to identify sources of "reserve" against cognitive decline in persons with MS. He has shown that persons with MS who lead more mentally-active lifestyles (e.g., reading, hobbies) are at lower risk for disease-related cognitive decline. Dr. Sumowski's current work seeks to identify a range of modifiable lifestyle factors contributing to reserve, with the goal of advancing primary prevention of cognitive difficulties due to MS.
Memory Treatments for Persons with Multiple Sclerosis
Memory deficits are among the most common cognitive difficulties experienced by persons with multiple sclerosis (MS), with negative consequences for employment and overall quality of life. There are currently no validated treatments for MS memory impairment. Dr. Sumowski has published early stage research investigating memory interventions through the use of cognitive strategies, lifestyle modifications, and pharmaceutical interventions. Dr. Sumowski is engaging in research to better understand the neural basis of memory deficits due to MS, which will inform the development of novel treatments with greater promise for success.
Sumowski JF, Rocca MA, Leavitt VM, Meani A, Mesaros S, Drulovic J, Preziosa P, Habeck CG, Filippi M. Brain reserve against physical disability progression over 5 years in multiple sclerosis. Neurology 2016 May; 86(21).
Sumowski JF, Rocca MA, Leavitt VM, Riccitelli G, Meani A, Comi G, Filippi M. Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 2016 Feb;.
Rocca MA, Amato MP, De Stefano N, Enzinger C, Geurts JJ, Penner IK, Rovira A, Sumowski JF, Valsasina P, Filippi M. Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis. The Lancet. Neurology 2015 Mar; 14(3).
Sumowski JF, Rocca MA, Leavitt VM, Dackovic J, Mesaros S, Drulovic J, DeLuca J, Filippi M. Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS. Neurology 2014 May; 82(20).
Sumowski JF, Leavitt VM. Body temperature is elevated and linked to fatigue in relapsing-remitting multiple sclerosis, even without heat exposure. Archives of physical medicine and rehabilitation 2014 Jul; 95(7).
Sumowski JF, Rocca MA, Leavitt VM, Riccitelli G, Comi G, DeLuca J, Filippi M. Brain reserve and cognitive reserve in multiple sclerosis: what you've got and how you use it. Neurology 2013 Jun; 80(24).
Sumowski JF, Chiaravalloti N, Erlanger D, Kaushik T, Benedict RH, DeLuca J. L-amphetamine improves memory in MS patients with objective memory impairment. Multiple sclerosis (Houndmills, Basingstoke, England) 2011 Sep; 17(9).
Sumowski JF, Wylie GR, Deluca J, Chiaravalloti N. Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve. Brain : a journal of neurology 2010 Feb; 133(Pt 2).