Jason C Kovacic, MD, PhD
- ASSOCIATE PROFESSOR | Medicine, Cardiology
Research Topics:Angiogenesis, Atherosclerosis, Cardiovascular
Dr. Jason Kovacic graduated from The University of Melbourne Medical School in 1994, and then undertook residency and cardiology specialty training in interventional cardiology at St. Vincent’s Hospital in Sydney, Australia. Becoming a Fellow of The Royal Australasian College of Physicians in 2003, Jason then completed a PhD in cardiovascular medicine at the Victor Chang Cardiac Research Institute. In 2007 Jason became a Fellow of The American College of Cardiology and relocated to the USA, to the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH) in Bethesda, Maryland. At the NIH, Jason discovered critical new pathways that lead to blockage of the body’s blood vessels. Jason then moved to The Mount Sinai School of Medicine in New York. In parallel with his vital ongoing research to define new ways to prevent and treat vascular disease, Jason is a practicing interventional cardiologist, specializing in treating blockages of the heart arteries. He has authored numerous scientific and clinical papers on heart and vascular disease, and serves on a number of NIH committees. He has a particular interest in the use of stem cells to understand and treat heart disease. His combined understanding and ability to treat heart disease places him in a unique position to offer the most comprehensive patient care.
- Acute Coronary Syndrome
- Cardiac Catherization
- Cardiovascular Disease
- Coronary Angioplasty
- General Cardiology
- Heart Disease
- Hyperlipidemia/High Cholesterol
- Valvular Heart Disease
- Vasospastic Disease
Multi-Disciplinary Training AreasDevelopmental and Stem Cell Biology [DSCB], Genetics and Genomic Sciences [GGS]
MBBS, University of Melbourne
Fellowship, Cardiology, Mount Sinai Hospital
The Kovacic Laboratory seeks to increase our understanding of blockages of arteries of the heart and other vessels, and develop cell, stem cell, and gene-based approaches for the prevention and treatment of cardiovascular disease.
Kovacic JC, Mehran R, Sweeny J, Li JR, Moreno P, Baber U, Krishnan P, Badimon JJ, Hulot JS, Kini A, Sharma SK. Clustering of Acute and Subacute Stent Thrombosis Related to the Introduction of Generic Clopidogrel. Journal of cardiovascular pharmacology and therapeutics 2013 Nov;.
Kini A, Yu J, Cohen MG, Mehran R, Baber U, Sartori S, Vlachojannis GJ, Kovacic JC, Pyo R, O'Neill B, Singh V, Jacobs E, Poludasu S, Moreno P, Kim MC, Krishnan P, Sharma SK, Dangas GD. Effect of bivalirudin on aortic valve intervention outcomes study: a two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2013 Nov;.
Ali ZA, Roleder T, Narula J, Mohanty BD, Baber U, Kovacic JC, Mintz GS, Otsuka F, Pan S, Virmani R, Sharma SK, Moreno P, Kini AS. Increased thin-cap neoatheroma and periprocedural myocardial infarction in drug-eluting stent restenosis: multimodality intravascular imaging of drug-eluting and bare-metal stents. Circulation. Cardiovascular interventions 2013 Oct; 6(5).
Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Tarzami ST, Kovacic JC, Kranias E, Hajjar RJ, Hadri L. Synergistic Role of Protein Phosphatase Inhibitor 1 and SERCA2a in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells. Circulation 2013 Nov;.
Kovacic JC, Sharma AB, Roy S, Li JR, Narayan R, Kim DB, Sharma SK, Kini AS. GuideLiner mother-and-child guide catheter extension: a simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions. Journal of interventional cardiology 2013 Aug; 26(4).
Dangas GD, Maehara A, Evrard SM, Sartori S, Li JR, Chirumamilla AP, Nomura-Kitabayashi A, Gukathasan N, Hassanin A, Baber U, Fahy M, Fuster V, Mintz GS, Kovacic JC. Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a three-dimensional intravascular ultrasound study. European heart journal cardiovascular Imaging 2013 Jul;.
Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma'ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a hemogenic program in mouse fibroblasts. Cell stem cell 2013 Aug; 13(2).
Kovacic JC, Limaye AM, Sartori S, Lee P, Patel R, Chandela S, Trost B, Roy S, Harari R, Narechania B, Karajgikar R, Kim MC, Krishnan P, Moreno P, Baber U, Mehran R, Dangas G, Kini AS, Sharma SK. Comparison of six risk scores in patients with triple vessel coronary artery disease undergoing PCI: Competing factors influence mortality, myocardial infarction, and target lesion revascularization. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013 May;.
Wood KC, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT. Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis. Arteriosclerosis, thrombosis, and vascular biology 2013 Aug; 33(8).
Baber U, Bander J, Karajgikar R, Yadav K, Hadi A, Theodoropolous K, Gukathasan N, Roy S, Sayeneni S, Scott SA, Kovacic JC, Yu J, Sartori S, Mehran R, Uribarri J, Badimon JJ, Muntner P, Moreno P, Kini AS, Sharma SK. Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity. Thrombosis and haemostasis 2013 Jul; 110(1).
Kini AS, Baber U, Kovacic JC, Limaye A, Ali ZA, Sweeny J, Maehara A, Mehran R, Dangas G, Mintz GS, Fuster V, Narula J, Sharma SK, Moreno PR. Changes in plaque lipid content after short-term intensive versus standard statin therapy: the YELLOW trial (reduction in yellow plaque by aggressive lipid-lowering therapy). Journal of the American College of Cardiology 2013 Jul; 62(1).
O'Neill B, Singh V, Kini A, Mehran R, Jacobs E, Knopf D, Alfonso CE, Martinez CA, Martinezclark P, O'Neill W, Heldman AW, Yu J, Baber U, Kovacic JC, Dangas G, Sharma S, Sartori S, Cohen MG. The use of vascular closure devices and impact on major bleeding and net adverse clinical events (NACEs) in balloon aortic valvuloplasty: A sub-analysis of the BRAVO study. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013 Feb;.
Roleder T, Suh W, Sharma R, Hecht H, Kovacic JC, Narula J, Kini AS. Plaques with high lipid burden: keeping the fat out of the fire. Heart (British Cardiac Society) 2013 Jul; 99(14).
Cubeddu RJ, Palacios IF, Blankenship JC, Horvath SA, Xu K, Kovacic JC, Dangas GD, Witzenbichler B, Guagliumi G, Kornowski R, Dudek D, Stone GW, Mehran R. Outcome of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention during on- versus off-hours (a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial substudy). The American journal of cardiology 2013 Apr; 111(7).
Kovacic JC, Fuster V. Atherosclerotic risk factors, vascular cognitive impairment, and Alzheimer disease. The Mount Sinai journal of medicine, New York; 79(6).
Kovacic JC, Fuster V. Smoking gun theory: angiographically normal or mild coronary plaque as a cause of myocardial infarction. Circulation 2012 Dec; 126(25).
Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Briley-Saebo KC, Tsimikas S, Witztum JL, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis. Journal of the American College of Cardiology 2012 Jul; 60(2).
Kovacic JC, Lee P, Karajgikar R, Baber U, Narechania B, Suleman J, Moreno PR, Sharma SK, Kini AS. Safety of temporary and permanent suspension of antiplatelet therapy after drug eluting stent implantation in contemporary . Journal of interventional cardiology 2012 Oct; 25(5).
Chirumamilla AP, Maehara A, Mintz GS, Mehran R, Kanwal S, Weisz G, Hassanin A, Hakim D, Guo N, Baber U, Pyo R, Moses JW, Fahy M, Kovacic JC, Dangas GD. High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study. JACC. Cardiovascular imaging 2012 May; 5(5).
Castellano JM, Kovacic JC, Sanz J, Fuster V. Are we ignoring the dilated thoracic aorta?. Annals of the New York Academy of Sciences 2012 Apr; 1254.