Jens Hansen, PhD
img_Jens Hansen
ASSISTANT PROFESSOR | Pharmacological Sciences
Research Topics
Bioinformatics, Cardiovascular, Cell Biology, Computational Biology, Kidney, Neurobiology, Systems Biology
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Dr. Hansen’s research focuses on the cell biology of multiple diseases and developmental changes. He has built the Molecular Biology of the Cell Ontology, a strictly cell biological ontology, that he uses to identify relevant subcellular processes (www.mbc-ontology.org). His research approaches employ dynamic models of pathway activities to identify how such subcellular processes interact with each other to generate a whole cell response. He developed a novel drug repurposing approach that counter-regulates disease-relevant pathway activities, independently of the genes involved. Dr. Hansen uses graph theoretical methods to relate differentially expressed genes and other experimental data to prior knowledge. His research topics include neurite outgrowth, aortic aneurysm development and progression, kidney physiology and pathophysiology as well as drug-induced cardiomyopathies. For more information please jhansenlab.org.

2008

Best medical dissertation award

Georg-August-University Göttingen, Faculty of Medicine, Germany

Publications

Selected Publications

Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients. Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Rajasree Menon, Leila Hejazi, Jian Jun Liu, Anthony Franzone, Helen C. Looker, Byeong Yeob Choi, Roman Fernandez, Manjeri A. Venkatachalam, Luxcia Kugathasan, Vikas S. Sridhar, Loki Natarajan, Jing Zhang, Varun S. Sharma, Brian Kwan, Sushrut S. Waikar, Jonathan Himmelfarb, Katherine R. Tuttle, Bryan Kestenbaum, Tobias Fuhrer, Harold I. Feldman, Ian H. de Boer, Fabio C. Tucci, John Sedor, Hiddo Lambers Heerspink, Jennifer Schaub, Edgar A. Otto, Jeffrey B. Hodgin, Matthias Kretzler, Christopher R. Anderton, Theodore Alexandrov, David Cherney, Su Chi Lim, Robert G. Nelson, Jonathan Gelfond, Ravi Iyengar. Journal of Clinical Investigation

An atlas of healthy and injured cell states and niches in the human kidney. Blue B. Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian Kalhor, Daria Barwinska, Edgar A. Otto, Michael Ferkowicz, Dinh Diep, Nongluk Plongthongkum, Amanda Knoten, Sarah Urata, Laura H. Mariani, Abhijit S. Naik, Sean Eddy, Bo Zhang, Yan Wu, Diane Salamon, James C. Williams, Xin Wang, Karol S. Balderrama, Paul J. Hoover, Evan Murray, Jamie L. Marshall, Teia Noel, Anitha Vijayan, Austin Hartman, Fei Chen, Sushrut S. Waikar, Sylvia E. Rosas, Francis P. Wilson, Paul M. Palevsky, Krzysztof Kiryluk, John R. Sedor, Robert D. Toto, Chirag R. Parikh, Eric H. Kim, Rahul Satija, Anna Greka, Evan Z. Macosko, Peter V. Kharchenko, Joseph P. Gaut, Jeffrey B. Hodgin, Richard Knight, Stewart H. Lecker, Isaac Stillman, Evren U. Azeloglu, Ravi Iyengar, Jens Hansen. Nature

Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice. Carlos A. Toro, Jens Hansen, Mustafa M. Siddiq, Kaitlin Johnson, Jiqing Cao, Adriana Pero, Ravi Iyengar, Dongming Cai, Christopher P. Cardozo. Neurotrauma Reports

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Hansen has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.