Jeremy M Silverman, PhD
- PROFESSOR | Psychiatry
Research Topics:Aging, Alzheimer's Disease, Autism, Genetics, Memory, Schizophrenia
Dr. Jeremy M. Silverman is a Professor in the Department of Psychiatry at the Mount Sinai School of Medicine and the Director of the Mount Sinai Family Studies Research Center which he established in 1988. He received his B.A. from Oberlin College (1978) and his Ph.D. in clinical psychology from New York University (1987). He joined the Psychiatry Department faculty at Mount Sinai in 1987. Dr. Silverman's major research interests pertain to the genetics of psychiatric disorders and, more specifically, the improved delineation of phenotypes and endophenotypes (intermediate phenotypes) associated with successful cognitive aging, dementia, schizophrenia, and other neuropsychiatric conditions in order to strengthen gene finding strategies. Dr. Silverman is also interested in the identification of non-genetic risk and protective factors associated with these conditions.
Multi-Disciplinary Training AreaNeuroscience [NEU]
BA, Oberlin College
PhD, New York University
MA, New York University
Specific Clinical/Research Interest: My group is especially focused on characterizing phenotypes and endophenotypes in successful cognitive aging, dementia, and schizophrenia for use in molecular genetic studies.
- Autistic endophenotypes and their associations to oxytocin and cholesterol
This is a study that assesses autistic children between the ages of 6 and 16 and their first-degree family members. Recent findings suggest that low levels of oxytocin and deficiencies in cholesterol synthesis may be related to symptoms of ASD and this study investigates the r...
Valerio D, Raventos H, Schmeidler J, Beeri MS, Villalobos LM, Bolaños-Palmieri P, Carrión-Baralt JR, Fornaguera J, Silverman JM. Association of apolipoprotein E-e4 and dementia declines with age. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2014 Oct; 22(10).
Guerrero-Berroa E, Ravona-Springer R, Heymann A, Schmeidler J, Hoffman H, Preiss R, Koifmann K, Greenbaum L, Levy A, Silverman JM, Leroith D, Sano M, Schnaider-Beeri M. Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes. International journal of geriatric psychiatry 2015 Sep;.
Schmeidler J, Lazzeroni LC, Swerdlow NR, Ferreira RP, Braff DL, Calkins ME, Cadenhead KS, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Olincy A, Nuechterlein KH, Radant AD, Seidman LJ, Siever LJ, Stone WS, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Silverman JM. Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings. Psychiatry research 2014 Sep; 219(1).
Silverman JM, Schmeidler J, Beeri MS, Rosendorff C, Sano M, Grossman HT, Carrión-Baralt JR, Bespalova IN, West R, Haroutunian V. C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging. Neurology 2012 Sep; 79(11).
Greenwood TA, Lazzeroni LC, Calkins ME, Freedman R, Green MF, Gur RE, Gur RC, Light GA, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL. Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study. Schizophrenia research 2016 Jan; 170(1).
Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, Rabinowitz J, Shulman C, Malaspina D, Lubin G, Knobler HY, Davidson M, Susser E. Advancing paternal age and autism. Archives of general psychiatry 2006 Sep; 63(9).
Silverman JM, Beeri MS, Schmeidler J, Rosendorff C, Angelo G, Mavris RS, Grossman HT, Elder GA, Carrion-Baralt J, West R. C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects. Age and ageing 2009 Mar; 38(2).
Beeri MS, Schmeidler J, Sano M, Wang J, Lally R, Grossman H, Silverman JM. Age, gender, and education norms on the CERAD neuropsychological battery in the oldest old. Neurology 2006 Sep; 67(6).
West RK, Beeri MS, Schmeidler J, Mitchell DB, Carlisle KR, Angelo G, Mavris R, Langhoff E, Rosendorff C, Silverman JM. Homocysteine and cognitive function in very elderly nondemented subjects. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2011 Jul; 19(7).
Greenwood TA, Beeri MS, Schmeidler J, Valerio D, Raventós H, Mora-Villalobos L, Camacho K, Carrión-Baralt JR, Angelo G, Almasy L, Sano M, Silverman JM. Heritability of cognitive functions in families of successful cognitive aging probands from the Central Valley of Costa Rica. Journal of Alzheimer's disease : JAD 2011; 27(4).