John Ci-jiang He
- PROFESSOR Medicine, Nephrology
- PROFESSOR Pharmacology and Systems Therapeutics
Print Profile
Research Topics
Training Areas
Education
M.D., Shanghai 2nd Medical School
Rui-Jin Hospital, Shanghai 2nd Medical School
General MedicineM.S., University of Paris VII
PhysiologyTenon Hospital
NephrologyPh.D., University of Paris VII
Tenon Hospital
INSERM U 64SUNY Health Science Center
General MedicineSUNY Health Science Center
General MedicineThe Mount Sinai Medical Center
Nephrology
Research
G-protein signaling pathways and their implication in kidney disease
The Nef-induced complex signaling network in kidney podocytes and its relevance to the pathogenesis of HIV-associated nephropathy is being studied. We found that Nef induces Src-Stats, Ras-cRAf-MAPK, and Rac1-PAK pathways leading to proliferation, dedifferentiation, and changes of the cytoskeletal structure in podocytes. We are investigating the relationship between Nef-induced signaling pathways and the changes of phenotype in podocytes by using dominant negative mutants or siRNA for these signaling molecules. We are also determining the phosphorylation of these signaling molecules in vivo by immunostaining using specific antibodies. We are trying to design and to test Nef inhibitory peptides for future therapeutic approach.Pathogenesis of glomerulosclerosis in diabetic nephropathy
The roles of cell proliferation, the fibrinolytic system, extracellular matrix turnover, and advanced glycation endproducts (AGE) have been studied in a variety of diabetic animal models including dietary AGE, AGE receptors, and their down-stream signaling pathways.Publications
Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He JJ, Vlassara H. Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J Am Soc Nephrol 2003; 14(3): 728-31.
Peppa M, He J, Hattori M, Mcenvoy R, Zheng F, Vlassora H. Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice. Diabetes 2003; 52(6): 1441-8.
Cai W, He JC, Zhu L, Peppa M, Lu C, Uribarri J, Vlassara H. High levels of dietary advanced glycation end products transform low-density lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in diabetic patients. Circulation 2004 Jul 20; 110(3): 285-91.
Lu C, He JC, Cai W, Liu H, Zhu L, Vlassara H. Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells. Proc Natl Acad Sci U S A 2004 Aug 10; 101(32): 11767-72.
He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest. 2004 Sept; 114(5): 643-51.
He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The Galpha o/i coupled cannabinoid receptor mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 2005 Sep 30; 280(39): 33426-34.
Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor induced neurite outgrowth is mediated by Rap1 activation through Galphao/I-triggered proteasomal degradation of Rap1GAPII. J Biol Chem 2005 Mar 25; 280(12): 11413-21.
Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS 2005 Nov 18; 19(17): 1975-80.
Schroppel B, He JC. Expression of Toll-like receptors in the kidney: their potential role beyond infection. Kidney Int 2006 Mar; 69(5): 785-7.
Lu TC, He JC, Klotman PE. Animal models of HIV-associated nephropathy. Curr Opin Nephrol Hypertens 2006 May; 15(3): 233-7.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. He did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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