Education
Ph.D., Cornell University
Statistics
Research
My research interests focus on both statistical theory and applications.
\r\n\r\nA major area of interest is the combinatorial construction of new experimental designs. Specifically, work is being done on the\r\nmathematical construction of sets of mutually orthogonal frequency rectangle designs, which are generalizations of latin square designs.\r\nGeneral classes of these designs as well as special classes, in which treatments are unconfounded with linear and quadratic\r\nrow-by-column interaction components, are being investigated. In addition, work is underway on the construction of asymmetrical\r\northogonal arrays, an area of discrete mathematics that plays a fundamental role in fractional factorial experimental designs.\r\n
\r\nI am also working on the statistical design, monitoring, and analysis of cancer clinical trials. Emphasis is on the proper design and\r\nanalysis of Phase I and Phase II clinical trials, as well as laboratory studies; and the application of stopping rules, multistage designs, and\r\nclassical experimental design theory to cancer clinical and laboratory study design.\r\n\r\n \r\n
Publications
Lamm C, Mandeli J, Kattan M. Evaluation of a home audiotape as an abbreviated test for Obstructive Sleep Apnea Syndrom (OSAS) in children. Pediatr Pulmonol 1999 Apr; 27(4): 267-72.
Pogo BG T, Melana SM, Holland J, Mandeli JF, Piloti S, Casalini P, Menard S. Sequences homologous to the MMTV env gene in human breast carcinoma correlate with overexpression of laminin receptor. Clin Cancer Res 1999; 5(8): 2108-11.
Mandeli JP. Construction of systematic row-colum designs with treatments unconfounded with the linear row X columns and quadratic row X columns interations. Stat & Prob Lett 1999; 42(3): 229-37.
Zier K, Johnson K, Johnson K, Maddux M, Sung M, Mandeli JP, Eisenbach L, Schwartz M. IFNgamma secretion following stimulation with total tumor peptides from autologous human tumors. J Immunol Methods 2000; 241(1-2): 61-68.
Ermekova V, Qiao J, Sauter B, Mandeli JP, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model. J Natl Cancer Inst 2000; 92(11): 931-36.
Sauter BV, Martinet O, Zhang WJ, Mandeli J, Woo SL. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc Natl Acad Sci 2000 Apr; 97(9): 4802-7.
Sung MW, Yeh H, Thung SN, Schwartz ME, Mandeli J, Chen S, Woo SL. Intratumoral Adenovirus-Mediated Suicide Gene Transfer for Hepatic Metastases from Colorectal Adenocarcinoma: Results of a Phase I Clinical Trial. Mol Ther 2001; 4(3): 182-91.
Ferrari A, Stone N, Stock R, Bednar M, Esseesse I, Harvinder S, Baldwin Y, Mandeli J. 13-cis Retinoic Acid and Complete Androgen Blockade in Advanced Hormone-Naive Prostate Cancer Patients: Report of a Phase II Randomized Study. J Clin Oncol 2002; 20(2): 538-44.
Serebrisky D, Cordero R, Mandeli J, Kattan M, Lamm C. Assessment of inspiratory flow limitation in children with sleep-disordered breathing by nasal cannula pressure transducer system. Pediatr Pulmonol 2002 May; 33(5): 380-87.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Mandeli did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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