John P Mandeli, PhD
- ASSOCIATE PROFESSOR | Environmental Medicine & Public Health
PhD, Cornell University
My research interests focus on both statistical theory and applications.
A major area of interest is the combinatorial construction of new experimental designs. Specifically, work is being done on the mathematical construction of sets of mutually orthogonal frequency rectangle designs, which are generalizations of latin square designs. In addition, work is underway on the construction of asymmetrical orthogonal arrays, an area of discrete mathematics that plays a fundamental role in fractional factorial experimental designs.
I am also working on the statistical design and analysis of cancer clinical trials. Emphasis is on the proper design and analysis of Phase I and Phase II clinical trials, as well as laboratory studies; and the application of stopping rules, multistage designs, and classical experimental design theory to cancer clinical and laboratory study design.
Chen HM, Ma G, Gildener-Leapman N, Eisenstein S, Coakley BA, Ozao J, Mandeli JP, Divino C, Schwartz M, Sung M, Ferris RL, Kao J, Pan PY, Ko E, Chen SH, Wang LH. Myeloid derived suppressor cells as an immune parameter in patients with concurrent sunitinib and stereotactic body radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr;.
Pogo BG T, Melana SM, Holland J, Mandeli JF, Piloti S, Casalini P, Menard S. Sequences homologous to the MMTV env gene in human breast carcinoma correlate with overexpression of laminin receptor. Clin Cancer Res 1999; 5(8): 2108-11.
Sabado RL, Pavlick A, Gnjatic S, Cruz CM, Vengco I, Hasan F, Spadaccia M, Darvishian F, Chiriboga L, Holman RM, Escalon J, Muren C, Escano C, Yepes E, Sharpe D, Vasilakos JP, Rolnitzsky L, Goldberg JD, Mandeli J, Adams S, Jungbluth A, Pan L, Venhaus R, Ott PA, Bhardwaj N. Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma. Cancer immunology research 2015 Mar; 3(3).
Mandeli JP. Construction of systematic row-colum designs with treatments unconfounded with the linear row X columns and quadratic row X columns interations. Stat & Prob Lett 1999; 42(3): 229-37.
Ngoma T, Mandeli J, Holland JF. Downstaging cancer in rural Africa. International journal of cancer. Journal international du cancer 2015 Jun; 136(12).
Zier K, Johnson K, Johnson K, Maddux M, Sung M, Mandeli JP, Eisenbach L, Schwartz M. IFNgamma secretion following stimulation with total tumor peptides from autologous human tumors. J Immunol Methods 2000; 241(1-2): 61-68.
Margolies L, Cohen A, Sonnenblick E, Mandeli J, Schmidt PH, Szabo J, Patel N, Hermann G, Weltz C, Port E. Digital breast tomosynthesis changes management in patients seen at a tertiary care breast center. ISRN radiology 2014 Mar; 2014.
Ermekova V, Qiao J, Sauter B, Mandeli JP, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model. J Natl Cancer Inst 2000; 92(11): 931-36.
Smith CB, Kale M, Mhango G, Neugut AI, Hershman DL, Mandeli JP, Wisnivesky JP. Comparative outcomes of elderly stage I lung cancer patients treated with segmentectomy via video-assisted thoracoscopic surgery versus open resection. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Mar; 9(3).
Sauter BV, Martinet O, Zhang WJ, Mandeli J, Woo SL. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc Natl Acad Sci 2000 Apr; 97(9): 4802-7.
Blank S, Wang Q, Fiel MI, Luan W, Kim KW, Kadri H, Mandeli J, Hiotis SP. Assessing prognostic significance of preoperative alpha-fetoprotein in hepatitis B-associated hepatocellular carcinoma: normal is not the new normal. Annals of surgical oncology 2014 Mar; 21(3).
Sung MW, Yeh H, Thung SN, Schwartz ME, Mandeli J, Chen S, Woo SL. Intratumoral Adenovirus-Mediated Suicide Gene Transfer for Hepatic Metastases from Colorectal Adenocarcinoma: Results of a Phase I Clinical Trial. Mol Ther 2001; 4(3): 182-91.
Cardenas-Goicoechea J, Shepherd A, Momeni M, Mandeli J, Chuang L, Gretz H, Fishman D, Rahaman J, Randall T. Survival analysis of robotic versus traditional laparoscopic surgical staging for endometrial cancer. American journal of obstetrics and gynecology 2014 Feb; 210(2).
Ferrari A, Stone N, Stock R, Bednar M, Esseesse I, Harvinder S, Baldwin Y, Mandeli J. 13-cis Retinoic Acid and Complete Androgen Blockade in Advanced Hormone-Naive Prostate Cancer Patients: Report of a Phase II Randomized Study. J Clin Oncol 2002; 20(2): 538-44.
Serebrisky D, Cordero R, Mandeli J, Kattan M, Lamm C. Assessment of inspiratory flow limitation in children with sleep-disordered breathing by nasal cannula pressure transducer system. Pediatr Pulmonol 2002 May; 33(5): 380-87.