Education
B.S., Nankai University
Ph.D., Institute of Microbiology, Chinese Academy of Sciences
Postdoctoral Fellowship, Mount Sinai School of Medicine
Biography
- Dr. Liu received his undergraduate degree in Microbiology from Nankai University in China in 1998, and a PhD from the Institute of Microbiology, Chinese Academy of Sciences in 2006. Dr. Liu started his postdoctoral training in Dr. Krulwich's laboratory at Mount Sinai School of Medicine in 2006. Dr. Liu was appointed to an Assistant Professor in the Department of Pharmacology and Systems Therapeutics in 2010. Dr. Liu is a member of Krulwich Laboratory in the Department of Pharmacology and Systems Therapeutics.
Research
Current research interests:
1) Special adaptation of the F1Fo-ATPsynthase in alkaliphilic Bacillus.
2) Studies of the role of cation/proton antiporters in pH homeostasis and sodium-resistance in alkaliphile.
Publications
Fujisawa M, Fackelmayer OJ, Liu J, Krulwich TA, Hicks DB. The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation. J Biol Chem 2010 Oct; 285(42).
Guo Y, Xue Y, Wang Q, Ma Y. Characterization and function analysis of a Halo-alkaline-adaptable Trk K+ uptake system in Alkalimonas amylolytica strain N10. Sci China C Life Sci 2009 Oct; 52(10).
Liu J, Fujisawa M, Hicks DB, Krulwich TA. Characterization of the Functionally Critical AXAXAXA and PXXEXXP Motifs of the ATP Synthase c-Subunit from an Alkaliphilic Bacillus. J Biol Chem 2009 Mar; 284(13).
Liu J, Krulwich TA, Hicks DB. Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4. Biochim Biophys Acta 2008 May; 1777(5).
Wei Y, Liu J, Ma Y, Krulwich TA. Three putative cation/proton antiporters from the soda lake alkaliphile Alkalimonas amylolytica N10 complement an alkali-sensitive Escherichia coli mutant. Microbiology (Reading, England) 2007 Jul; 153(Pt 7).
Yuan S, Ren P, Liu J, Xue Y, Ma Y, Zhou P. Lentibacillus halodurans sp. nov., a moderately halophilic bacterium isolated from a salt lake in Xin-Jiang, China. International journal of systematic and evolutionary microbiology 2007 Mar; 57(Pt 3).
Wang N, Zhang Y, Wang Q, Liu J, Wang H, Xue Y, Ma Y. Gene cloning and characterization of a novel alpha-amylase from alkaliphilic Alkalimonas amylolytica. Biotechnology journal 2006 Nov; 1(11).
Liu J, Xue Y, Wang Q, Wei Y, Swartz TH, Hicks DB, Ito M, Ma Y, Krulwich TA. The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment. Journal of bacteriology 2005 Nov; 187(22).
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Liu did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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