- ASSOCIATE PROFESSOR Developmental and Regenerative Biology
B.S., Kansas State University
D.V.M., Kansas State University
Post-Doctoral Research, Baylor College of Medicine
ResearchSpecific Clinical/Research Interest: Stem Cells/Microenvironment/Stem Cell Niche, Cell, Developmental, Molecular regulation of hematopoietic stem cell self renewal and differentiation, molecular interaction of stem cells and microenvironmental elements, ie. the stem cell niche regulation of stem cells.
Current Students: Jiajing Qiu
Postdoctoral Fellows: Carlos Filipe Pereira
Research Personnel: Xiaohong Niu
Summary of Research Studies:
Primary research interest in defining the cellular and molecular nature of the hematopoietic stem cell niche, particularly the molecular cross-talk between stem cells and their niche. First approach a genomic profile of a stem cell supporting stromal cell line. Profile led to mouse models that manipulate and allow visualization of stem cells in their niche.
Moore KA, Ema H, Lemischka IR. In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 1997 Jun 15; 89(12): 4337-4347.
Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997 Apr 15; 94(8): 4011-4016.
Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR. The genetic program of hematopoietic stem cells. Science 2000 Jun 2; 288(5471): 1635-1640.
Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A 2002 Oct 1; 99(20): 13061-13066.
Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science 2002 Oct 18; 298(5593): 601-604.
Moore KA, Lemischka IR. Stem cells and their niches. Science 2006 Mar 31; 311(5769): 1880-1885.
Chateauvieux S, Ichanté JL, Delorme B, Frouin V, Piétu G, Langonné A, Gallay N, Sensebé L, Martin MT, Moore KA, Charbord P. Molecular profile of mouse stromal mesenchymal stem cells. Physiological genomics 2007 Apr; 29(2).
Krasnov P, Michurina T, Packer MA, Stasiv Y, Nakaya N, Moore KA, Drazan KE, Enikolopov G. Neuronal nitric oxide synthase contributes to the regulation of hematopoiesis. Molecular Medicine 2008; 14(3-4): 141-149.
Glauche I, Moore K, Thielecke L, Horn K, Loeffler M, Roeder I. Stem cell proliferation and quiescence--two sides of the same coin. PLoS computational biology 2009 Jul; 5(7).
Schaniel C, Moore KA. Genetic models to study quiescent stem cells and their niches. Annals of the New York Academy of Sciences 2009 Sep; 1176.
Moore K. A roundabout way to the niche. Cell stem cell 2011 Jan; 8(1).
Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Z, Suda T, Lemischka IR. Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Proceedings of the National Academy of Sciences of the United States of America 2011 Feb; 108(6).
Schaniel C, Sirabella D, Qiu J, Niu X, Lemischka IR, Moore KA. Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood 2011 Jun;.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Moore did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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