Kevin A. Kelley

  • RESEARCH PROFESSOR Developmental and Regenerative Biology
  • ASSOCIATE PROFESSOR Neuroscience
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Education

  • Ph.D., Johns Hopkins University
    Molecular Biology

  • Yale University School of Medicine
    Molecular Neuroscience

Biography

Awards

  • 1993 - 1997
    Irma T. Hirschl Career Scientist Award

  • 1987 - 1988
    Swebilius Cancer Research Award

  • 1985 - 1987
    Postdoctoral Fellow
    American Cancer Society

Research

The Mouse Genetics Shared Research Facility (SRF) was established in 1999 to provide the faculty of Mount Sinai with a state-of-the-art facility for the production of novel, genetically manipulated mouse lines. The research efforts of this group include microinjection of gene fragments for production of transgenic mice, microinjection of selected ES cells for the production of gene-targeted mouse lines, rederivations of mouse lines for removal of mouse pathogens, and cryopreservation of mouse gametes. In addition to these research goals, the SRF provides investigators with an outstanding resource for aid with transgene design, protocols for ES cell culture, and general assistance with all phases of mouse genetics. In addition to the goals of the SRF, my collaborative research interests using the mouse as a model system span several areas of developmental biology as evidenced by the following publications.

For detailed information, please consult our shared research facility website.


Publications

Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley K, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR. Targeted deletion of the vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron .1999; 23: 537-548.

Friedrich VL, Holstein G Jr, Li X, Gow A, Kelley K, Lazzarini RA. Intracellular distribution of transgenic bacterial-galactosidase in CNS neurons and neuroglia. J Neurosci Res 1993; 36: 88-98.

Kelley K, Friedrich VL, Sonshine A, Hu Y, Lax J, Li J, Drinkwater D, Dressler H, Herrup K. Expression of Thy-1/lacZ fusion genes in the CNS of transgenic mice. Brain Res Mol Brain Res 1994; 24: 261-274.

Kelley K, Ho L, Winger D, Freire-Moar J, Borelli B, Aisen P, Pasinetti GM. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase 2. Am J Pathol 1999; 155: 995-1004.

Dracheva S, Xu M, Kelley K, Haroutunian V, Holstein GR, Haun S, Silverstein JH, Sealfon SC. Paradoxical behavior of dopamine D1 receptor transgenic mice. Exp Neurol 1999; 157: 169-179.

Stecca B, Southwood CM, Gragerov A, Kelley K, Friedrich VL, Gow A. The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci 2000; 1: 4002-4010.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Kelley did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Address

Atran Berg Laboratory Building Floor 7 Room 10E
1428 Madison Avenue
New York, NY 10029

Address

Atran Berg Laboratory Building Floor 7th Floor Room 10E
1428 Madison Avenue
New York, NY 10029

Tel: 212-241-3991
Fax: 212-860-9279