Kothandaraman Purushothaman, MD
- ASSISTANT PROFESSOR | Medicine, Cardiology
- ASSISTANT PROFESSOR | Pathology
Dr.K-Raman Purushothaman has obtained his M.D degree from Madras University and completed his post-doctoral training in pathology at Madras Medical College and Jawaharlal Nehru Institute of Post Graduate Medical Education & Research Center, in India. He joined with Dr.Pedro Moreno's Cardiovascular Research Laboratory as Director of Histology at the University of Kentucky and involved in the histopathological evaluation of human and experimental atherosclerosis.
His current research focuses on histopathologic quantification of atherosclerosis. He is involved in detailed advanced immunohistochemistry techniques using the double- labeling, bi-color chromogens for studying the neovascularization of the plaque. He is also involved in the study of intimal, medial and adventitial, plaque compositional changes in the plaque progression and regression and the risk factors (diabetes mellitus, cigarette smoking and hypercholesterolemia) involving the association in inflammation and plaque rupture.
His animal experimental studies involves pre-clinical evaluation of drug eluting stents by analyzing the effects of drug eluting stents in stabilizing the vulnerable rabbit aortic plaques and study the plaque composition. His efforts will be to study the neovascularization and the implications in plaque rupture in diabetics versus non-diabetics based on the preliminary analysis in human aortic atherosclerotic plaques and to develop an animal model to study the mechanism involved in neovascularization in atherosclerotic plaques.
Moreno PR, Lodder RA, Purushothaman KR, Charash WE, O'Connor WN, Muller JE. Detection of lipid pool, thin fibrous cap and inflammatory cell infiltration in human aortic atherosclerotic plaques by near infrared spectroscopy. Circulation 2002 February 26; 105(8): 923-927.
Moreno PR, Purushothaman KR, Fuster V, O'Connor WN. Intimomedial damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta. Implications for plaque vulnerability Circulation 2002; 105: 2502-2509.